98 TRANSACTIONS LIVERPOOL BIOLOGICAL SOCIETY. 



seen under the microscope, but rather a selection of all 

 the different kinds of cells which could be seen at the 

 same time by an oil-immersion lens. There was a large 

 amount of fine cell-debris, but neglecting this, we see thai 

 we have the elements of a mixed-cell sarcoma. The 

 commonest cells present were the small spherical ones with 

 large nuclei represented at A in the figure. There were 

 a few spindle cells (B), but not many. Here and there 

 were cells containing* in addition to one or two typical 

 nuclei a spherical body surrounded by a concentric 

 space. These inclusions did not take nuclear stains. I 

 think they belong to the category of formations repre- 

 sented by " Russell's bodies," and have no significance 

 except that they represent morbid changes in the cancer 

 cells. There were other cells (D) containing numbers of 

 chromidial bodies : these represent nuclear fragmentation 

 or nucleolar formations. Then there were the rather 

 extraordinary cells represented at E. These are poly- 

 morphic, or " amoeboid." They may contain more than 

 one nucleus, though usually one only. Their cytoplasm 

 was usually highly vacuolated. They would be of interest 

 if one could be sure that they existed, as they are drawn, 

 in the fresh, unfixed tissue, but a dried smear is a type of 

 preparation from which one may expect anything, so 

 I think the forms of these cells are artificial and due to 

 the process of smearing. Finally there were multi- 

 nuclear cells such as are represented at F. Thus we 

 have a substance containing cell-debris, unaltered cells of 

 various forms, and cells altered as the result of the 

 degeneration of the sarcoma and the process of fixation. 



One of the nodular bodies contained in the tumour 

 was fixed, hardened and cut. Figs. 4 and 5 of Plate VI 

 show the structure of these bodies. They were " cheesy " 

 in consistence, but cut in the microtome after embedding 



