SEA-FISHERIES LABORATORY. 99 



in paraffin without difficulty. Fig. 4 is quite typical, and 

 shows a substance consisting of a granular matrix in 

 w T hich are numerous isolated cells. Some of these cells 

 are " spindles," often lying with their long axes in the 

 same direction, but not arranged in any way. There are 

 larger spherical or irregularly shaped cells, and many 

 small spherical ones. That is the general structure of the 

 nodule, except that here and there the matrix becomes 

 hyaline, and the cells disappear or are represented only 

 by nuclear fragments. 



For the most part, both cytoplasm and nuclei of the 

 cells stain rather lightly with methyl-blue eosin (more 

 lightly by far than one sees in sarcomatous tissues when 

 employing this stain). Here and there were small 

 rounded bodies consisting apparently of a fused mass of 

 cells and surrounded with a rather definite fibrous capsule. 

 These are shown in fig. 5 of Plate VI. Evidently they 

 are the cyst-like structures seen in the examination of the 

 fresh material. 



What we have, therefore, in the semi-liquid and 

 nodular parts of the tumour is an autolysing mixed-cell 

 sarcoma. Degeneration has proceeded very far, with the 

 result that little of the original structure of the tumour 

 has persisted. 



Parts of the muscle substance cut out from the 

 margins of the tumour were now embedded and cut, but 

 most of these showed no sarcomatous tissue, only muscle 

 fibres, attenuated, so to speak, and separated from each 

 other by spaces larger than normal. But on examining 

 these tissues some were found in which the sarcoma could 

 be detected by its difference in consistency. A section 

 through such a part is shown in Text-fig. 4. 



Here we have, plainly, a sarcomatous tissue which 

 has probably ceased to infiltrate the normal tissue. On 



