SEA-FISHERIES LABORATORY. 101 



Some are homogeneous and with a distinct sarcolemma, 

 but with no trace of striation, while others show the 

 muscle-fibre substance in a state of fragmentation and 

 with either no trace of sarcolemma, or with this invest- 

 ment in tatters, so to speak. Here and there are traces of 

 the utter disintegration of the fibres. What we have 

 here is, therefore, the degeneration of the surrounding 

 un-infiltrated muscle substance as the result of the 

 products of the necrosis of the sarcoma. 



The field B, that is fig. 4, is a small part of the 

 otherwise broken-down sarcoma, where some remains of 

 structure can be seen. It is here a " spindle-celled " or 

 an " oat-cell" sarcoma, and little autolytic change or 

 structural disintegration is evident. There are two 

 "giant-cell" masses, that is, groups of "clumped" or 

 "agglutinated" cells. These are not surrounded by a 

 capsule, but one can see a roughly concentric arrange- 

 ment of the spindle cells round them. They are probably 

 the same kind of bodies as are represented in fig. 5, except 

 that in the latter case a process of fibrosis has taken place 

 round the cell masses. Fig. 4 probably represents the 

 original structural form of the sarcoma. 



Fig. 6 represents the details of the capsule shown at A 

 in Text-fig. 4. The capsule is a structure consisting of 

 small spindle cells, but the proportions of the " spindles " 

 vary greatly. The lower part of the figure represents 

 the left part of the capsule as seen in Text-fig. 4. Here 

 the spindle cells break down, or fuse together, so that the 

 cell outlines become obscure or quite absent; and the 

 nuclei disintegrate. A Mallory-stained preparation 

 showed that the inner part of the capsule was greatly 

 altered. The upper part of the figure represents the 

 semi-liquid cell debris already spoken of. 



Thus the sarcoma was originally a multiple one. 



