148 PROFESSOR RUTHERFORD ON THE 
Necrorsy.—The mucous membrane of the duodenum, and to a slight ex- 
tent below it, was very vascular, and this part of the intestine contained a con- © 
siderable quantity of a slightly brown fluid, thereby affording evidence of a 
purgative effect. 
Erperiment 8. Dog that had fasted eighteen hours. Weight 6°6 kilo- 
grammes.—Six grains podophyllin in 9 cc. water injected into duodenum (p, 
fig. 8). The subsequent rise in the bile-secretion is very evident. The secretion 
attained its maximum between three and four hours after the administration of 
the podophyllin. As in the previous case, the effect on the liver had very 
ereatly diminished by the end of the sixth hour after administration. 
Necrorsy.—Distinct, though not abundant, evidence of purgative action in 
small intestine, and decidedly increased vascularity of the mucous membrane 
in its upper two-thirds. Nothing remarkable in stomach or large intestine. 
Fig. 8.—Secretion of bile before and after 6 grains of resina podophylli in 9 ce. water were 
injected into duodenum at p. 
Experiment 8. 
Secretion of bile ae enue Secretion of bile Secretion of bile 
per 15”. [eee kilogramme of | per 15”, per kilogramme of 
| dog: per hour. dog: per hour, 
ce. cc. % 
0°3 0°57 
Ol 0°52 
0°07 | 0-6 
|. 908 | oo 
: | 0°6 
oe ) | 0°75 
0-05 0°042 cc. } as 0°47 ec 
0°03 | 0-8 
i 0°75 
OL | 0°75 
0°15 | 0°62 
| 0°2 ] 0°52 
| 0°27 | 0°42 
| 0°52 | 0°35 
0°52 | 0°35 
Probably every one will be struck by the slowness and the small extent of 
the purgative action in these experiments, notwithstanding the large doses of 
