PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 149 
podophyllin. That this was owing to the insolubility of podophyllin in water 
is probable from the two following experiments. ZwICKE, HAGENTORN, and 
KOuter having shown (Fraser’s Report in Op. vii., vol. v. p. 393) that convolvulin, 
elaterin, and some other substances have no purgative action unless they come 
in contact with bile—which, therefore, appears to be a solvent for them—it 
occurred to us that the tardy action of the podophyllin might be owing to the 
non-entrance of the bile into the intestine. Accordingly in the next experi- 
ment, the podophyllin was suspended in bile. 
Experiment 9. Dog that had fasted eighteen hours. Weight 11 kilo- 
grammes.—12°2 cc. bile injected into duodenum (8, fig. 9). Unfortunately, there 
is a hiatus in the curve immediately before the injection, owing to a loss of the 
bile ; nevertheless it is evident that increased bile-secretion followed the injec- 
tion when the biliary flow had become fairly constant. Nine grains podo- 
phyllin, triturated in a mortar with 12 ‘cc. bile, were injected into the duodenum 
Experiment 9. 
Secretion of bile 
per kilogramme of 
dog : per hour. 
Secretion of bile | 
per 15”. 
bo po bo De 
Hb DOR OF 
s 
1 2 3 4 5 6 
Fig. 9.—Secretion of bile before and after podophyllin, 0. 122 cc. bile; 
Pp, 9 grains resina podophylli in 12 ce. bile injected into duodenum. 
SOOM HE HH pen bo bP 
OU CO EDD O10 C9 OD CO DD HB OO 
(p). A rapid increase in the bile-secretion ensued ; but it soon diminished, and 
three hours after the injection it was lower than it had ever been. In this 
remarkable experiment, therefore, the diminution of bile-secretion after podo- 
phyllin was far more remarkable than its increase ; indeed, the increase might 
VOL. XXIX. PART I. 2Q 
