150 PROFESSOR RUTHERFORD ON THE 
possibly have been owing to the injected: bile, and not to the podophyllin, 
Towards the close. of the experiment the pulse became weak, but not exces- 
sively so. 
NECROPSY. Bavinwoas membrane of stomach and whole length of small in- 
testine intensely red. The small intestine contained a large quantity of fluid, 
The large intestine contained a considerable quantity of liquid feecal matters. 
There was, therefore, abundant evidence that excessive ipueoacn was immi- 
nent. 
In this experiment, the mmeestinal irritation and the purgative effect were 
far greater than they were in any of the previous experiments with podophyllin, 
and it is evident that the principal change in the bile-secretion was diminution. 
It therefore appeared that, with a powerful solvent such as the bile, nine grains 
of podophyllin produced a. too violent effect upon the alimentary canal. The 
previous experiments having shown that, with a slighter action on the intestine, 
there was a more powerful action on the liver, suggested that with a smaller 
dose of podophyllin given in the biliary solvent, an action on the liver would 
be evident, and that this would follow the injection more speedily than it had 
done in the experiments where the podophyllin was. not given in a state of 
solution. The next experiment realised this anticipation in a very striking 
manner. 
Experiment 10. hee that had fasted nineteen hours. Weight 17:1 kilo- 
grammes.—The bile-secretion was about 2 cc. per fifteen minutes before 
injection into the duodenum of 6 cc. bile and 6 cc. of water (4, fig. 10). The 
subsequent increase of secretion was trivial. An hour after this, four grains 
podophyllin, in the same quantity of bile and water, were injected (p). 
About half an hour afterwards a great acceleration of the biliary flow began, 
and lasted about an hour. In one of the periods of fifteen minutes, no 
less than 5°8 cc. of bile were secreted ; a quantity never noticed in any 
other experiment, even on larger dogs. When this great hepatic excitement 
had disappeared, 6 cc. of bile and 6 cc. of water were again injected (0’), 
as in the first instance. The fall in the secretion was for a time arrested ; 
but within three hours after the administration of the podophyllin, the 
action of the liver had almost entirely ceased. The pulse was weak, but not 
extremely so. 
Necropsy. — The mucous membrane of the duodenum was mtilel 
vascular, but that of the remainder of the small intestine did not show an 
increased vascularity nearly so great as in the previous experiment. The 
upper three-fourths of the small intestine contained very decided evi- 
dence of purgative effect. The gastric mucous membrane had a dull red 
appearance. 
