PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 161 
copeeia” was prepared and concentrated until 5 cc. contained the active part of 
forty-five grains of senna ; a small dose for a man. 
Experiment 15. Dog that had fasted eighteen hours. Weight 23:1 kilo- 
grammes.—+ cc. bile and 5 cc. water were injected into duodenum at 6 (tig. 
15), and 4 cc. bile, with 5 cc. infu- 
sion of senna of the strength above 
mentioned, at s, s’, s’, s’’. There 
was only a slight increase in the 
biliary secretion. 
Necropsy. — The senna had 
_ passed through the whole length 
of the small and had entered the 
large intestine. The amount of 
fluid in the small intestine was 
103 cc., showing that a very con- 
siderable purgative effect had been 
produced. 
Result of Experiment with 
Senna. —- Although senna is a 
powerful intestinal, it is a very 
feeble hepatic stimulant. RonrIc’s 
error with regard to it was doubt- 
less the result of his faulty method. 
Fig. 16.—Secretion of bile before and after 60 grains extract 
of colchicum in 10 cc. water were injected into the 
duodenum at c. 
Experiment 16. 
aqueous extract of colchicum of the 
q Secretion | Secretion 
ecretion of bile per Secretion of bile per 
ACTION OF COLCHICUM. of bile per | kilogramme | of bile per sctlogenanroe 
alla\/F of ace per | alive of dog: per 
: hour. 
Colchicum has been recom- oF | a 
mended by Garrop as a chola- — = eae | 
gogue in cases of gout, but its ie wl ees | 
i ; A 3 0-5. 0'138 cc. |} 1°45 0246 cc. 
action on the liver has not hitherto ope | et 
iT a1 ¢‘- 1 7 
| been tested by direct experiment. rm |) aos |) lea 
Two grains of the extract is the 0-207 ce Bee () 
maximum dose for a man. uae s ao 
Experiment 16. Dog that had 1 han | ee page 
¥ i 1:05 ire: 
fasted sixteen hours. Weight 23°5 0°95 Hi 
_kilogrammes.—Sixty grains of the al 
“British Pharmacopceeia” in 10 cc. of water were injected into the duodenum 
_ (¢, fig. 16). In an hour the biliary secretion began to increase, and five hours 
| after the injection it was nearly five times more than before the drug was 
given. The secretion then fell, and just at the close of the experiment a 
VOL. XXIX. PART I. Pa 
