162 PROFESSOR RUTHERFORD ON THE 
large quantity of liquid feces was discharged. The rise in the curve in 
fig. 16 suggests a very powerful stimulation of the liver, but it must be 
remembered that the animal was of large size, and the table of numbers 
shows that the secretion per kilogramme of dog never went higher than 
0°453 cc. ; 
Necropsy.—There was great vascularity of the upper four-fifths of the 
mucous membrane of the 
small intestine. The vas- 
cularity of the duodenum 
was intense. The mucous 
membrane of the large 
intestine was also unusu- 
ally vascular. The gastric 
mucous membrane was 
pale. There was evidence 
of considerable hydroca- 
Fig. 17.—Secretion of bile before and after 60 grains of aqueous extract tharsis in the small in- 
of colchicum in 10 ce. of water were injected into duodenum at c. ‘ . 
testine. The large intes- 
tine was empty, owing to 
the recent discharge of 
feecal matter. 
Experiment 17. 
| 
: | Secretion | : Secretion 
| SRE | Steetet. | SIRS | URES, | Keperiment.17. Dog that 
Bs eed ae of dog: Per | had fasted eighteen hours. 
——| |— | Weight 23°6 kilogrammes. 
ie ve | —Sixty grains of aqueous 
O47 1) ae. ane extract of colchicum in 
es j ue 10 cc. of water were in- 
oes | es jected into the duodenum 
ee i i186 ec ee (c, fig. 17).  Althougm 
vas J 1 the biliary flow thereafter 
1°02 | 0-75 | varied much, a decided 
1°02 0°55 ' increase was evident an 
1°22 kata 0-4 hour and a half after the 
i a administration of the drug. 
| 
| 
| 
| 
The increase lasted about 
four hours, after which the secretion gradually fell. The liver was certainly 
excited, but not powerfully, for the secretion of bile per kilogramme of dog 
did not rise above 0:205 ce. 
Necropsy.—There was increased vascularity of the mucous membrane of 
the upper three-fourths of the small intestine. The whole small intestine 
contained evidence of powerful cathartic action. 
