| injected at 0, and again at o’. 
PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 165 
ACTION OF CastTor-OIL. 
As Rouric experimented with castor-oil (Op. vi.), and found that it has 
scarcely any effect on the hepatic secretion, it appeared desirable to emulsify 
the oil with bile, so that its condition in the intestine might more closely re- 
semble that in any normal case. 
Experiment 20. Dog that had fasted eighteen hours. Weight 7°7 kilo- 
grammes.—3 cc. of bile were injected into the duodenum at b (fig. 20). One 
ounce of castor-oil, emulsified with 3 ce. 
of bile, was injected into the duodenum 
at c,and againat c’. A slight increase 
in the bile-secretion followed the second 7 J 
dose; but as its extent was trifling, it 
should probably be disregarded. There = 
was a great diminution towards the : 
close of the experiment. sai 
Necropsy.—There was decided evi- j 
dence of purgation in the small intes- Fig. 20.—Secretion of bile before and after castor-oil. 
: 3 ce. of bile injected into the duodenum at 0b. 
tine. There was no unusual redness The same, with one ounce of castor-oil, given at c, 
[sa 
oo 
> 
SS 
> 
_ of the mucous membrane, save at the and at c’. 
lower part of the duodenum. 
Experiment 21. Dog that had fasted eighteen hours. Weight 24°5 kilo- 
grammes.—3s cc. bile injected into 
the duodenum at e (fig. 21), and 
28°5 ce. castor-oil with 3 cc. bile 
2 
15 
Necropsy.—The oil had ex- 
tended throughout the whole ! 
length of the small and large in- 
testine. There was evidence of 05 
profuse purgative action, but the 
increased vascularity of the in- 
_ testinal mucous membrane was 1 2 3 4 5 6 7 8 
slight. Fig. 21.—Secretion of bile before and after castor-oil. 38 cc. 
bile injected into duodenum ate. The same with 28'5 ce. 
castor-oil injected at 0, and again at o’. 
Result of HEaperiments with 
Castor-Oil.—It stimulates the in- 
testinal glands, but not the liver. It lowers the bile-secretion, probably 
indirectly, owing to its action on the intestinal glands. The appearance of the 
‘intestinal mucous membrane was in complete harmony with the belief that 
castor-oil is an exceedingly bland purgative. 
| VOL. XXIX. PART I. ee 
