168 
Experiment 24. Dog that had fasted eighteen hours, 
(fig. 24). 
NECROPSY.— 
Fig. 
6 ce. 
24.—Secretion of bile before and after 
ammonium chloride. 
jected into duodenum at w. 
with 6 grains ammonium chloride, 
water in- 
The same 
in- 
jected at a, and again at @’ and an” (18 
gr ains giv en 
in all). 
PROFESSOR RUTHERFORD ON THE 
Weight 7 kilogrammes 
Small intestine, in nearly its whole length, contained a large 
quantity of a very watery fluid. The vascu- 
larity of the mucous membrane was only 
slightly increased. 
Experiment 25. Dog that had fasted twenty 
hours. Weight 13:7 kilogrammes (fig. 25), 
Necropsy.—Somewhat increased vascular- 
ity of the mucous membrane of the upper 
three-fourths of the small intestine. There 
was evidence of a moderate purgative effect. 
Result of Experiments with Ammonium Chloride.—The two experiments with 
this substance show that doses capable of stimulating the intestinal glands did 
65 
£0 
1 
2 
Fig. 25. 
4 ce. 
3 
4 
a 
—Secretion of bile before and after ammonium chloride. 
bile and 5 ce. water injected into duodenum at 0. 
The same with 10 grains ammonium chloride injected at 
a. Ata’ the same ‘with 20 grains, at aw” the same with 40 
grains, at a” 
the same with 60 grains. 
Experiment 25. 
not excite the liver. The effect on 
the biliary secretion is comparable 
to that of sulphate of magnesia (Ex- 
periments 18 and 19), or other sub- 
stance having a stimulant effect on 
Lieberkiihn’s glands, but not on the 
liver. In proportion to the body- 
weight, the doses we gave to the 
dog were greater than those given 
to man, and therefore it need not 
Secretion 
of bile per 
nee 
Secretion 
of bile per 
kilogramme 
of dog ; per 
hour. 
Secretion 
be expected that, in the doses re- 
i ae} commended by Dr Stewart, a pur- 
eas gative effect should be observed in 
of dog : per man. Inasmuch, therefore, as these 
experiments give no evidence of any 
stimulant action of this substance on 
the liver, and seeing that in the 
human subject also there is no cer- 
tain evidence of its having any direct 
cholagogue action, one is led to ask 
whether the effects observed by Dr 
STEWART, in cases of chronic hepatic 
torpidity, may not have been the 
et result of some indirect action on the 
liver, due to a slight but prolonged 
increase of the intestinal secretion, 
or to some effect on the system generally. Our experiments supplement Dr 
