170 PROFESSOR RUTHERFORD ON THE 
The exact effect of this was not ascertained, owing to the loss of the bile 
secreted during one of the periods. About an hour after this, 0°25 cc. bile, 
05 cc. rectified spirit, and 
1:25 cc. water, were injected 
(0°). This having scarcely 
any effect, it was given with 
four grains of scammony 
resin at s, and again at 
Fig, 254. Sesretion of bie befor end alee eummzoni g Ti even tial No Wend Onn aia ame 
mony was doubled, and this 
dose was given at s’’ and s’”. There was an increase of the biliary secretion 
after the first two doses of scammony, but after the third and fourth the 
secretion diminished. 
As two experiments (73, 74) in which alcohol was given, prove that it 
certainly does not augment the biliary secretion, this experiment shows that 
scammony is a hepatic stimulant, although not a powerful one. 
Necropsy.—The scammony had passed along two-thirds of the small intes- 
tine. There was decided evidence of purgation, but no remarkable increase in 
the vascularity of the mucous membrane. 
From these experiments it appears that scammony is a hepatic stimulant of 
feeble power, and it seems unnecessary to detail them further. 
ACTION OF RESINA EUVONYMI oR “ EUVONYMIN.” 
It is stated by Woop and Bacue (Op. x. p. 374), that “the precise virtues 
of the bark of Huwonymus atropurpureus have not been determined.” Mr C. A. 
Santos—quoted by them—describes it as “tonic, hydragogue cathartic, diuretic, 
and antiperiodic.” Dr TipyMaANn informed them that he had obtained useful 
effects from it, as an alterative of the hepatic function. Woop and BacuHe 
conclude that “on the whole its character is somewhat uncertain; and it might 
well form a subject of further examination.” The American “ Eclectics”* give 
“euonymin” as a mild aperient in doses of from 1 to 2 grains. The substance 
used by them, however, is an impure resin, only a portion of which consists of 
the active principle—the «we euonymin. Mr CLoTuier (Op. x. /. ¢.) found it 
to produce active purgation without griping. The substance employed in our 
experiments is an impure resin, said to be prepared by precipitating the tincture 
of euonymin with water acidulated with hydrochloric acid, and mixing the 
* The American “ Eclectics” are charlatans, who nevertheless employ substances many of which 
are of undoubted value, and have received too little attention from the physician. 
