PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 171 
precipitate with an equal bulk of some inert powder. It was obtained from 
TiwpEN & Co. of New York, through Messrs Duncan & FLockHartT of 
Edinburgh. 
Experiment 27. Dog that had fasted seventeen hours. Weight 19 kilo- 
grammes (fig. 27).—2 cc. bile and 2 cc. water injected into duodenum at 6. Five 
grains of euonymin in the same fluid injected at e. 
The irregularity in the biliary flow in this case was certainly owing to an 
irregularity in secretion, for the cannula was perfectly patent throughout the 
whole of the experiment. The irregularity did not consist in the bile being 
Experiment 27. 
| Secretion of bile Secretion of bile 
ner 15”, per kilogramme of 
I | dog: per hour. 
| —— —— ~--- ————— 
ee. | 
1°82 
| 1°2 
16 
| 1°85 
2°2 
13 
1°95 
22 
(foresee 
1°35 
17 
1-2 
Fee | \ 02578 ce. 
0-95 | 
——— 
2°6 
1°5 
1°5 
16 
2°95 | 
se hous ee. 
Fig. 27.—Secretion of bile before and after euonymin. 2 ce. bile 27 
and 2 cc, water injected into duodenum at 6. 5 grains of 11 | 
euonymin, together with the above fluid, injected at e. ay 
11 | 
ean | 
| 
expelled in jets, as might have been expected had it been owing to contraction 
of the larger bile-ducts at intervals; but there was a rapid aud steady flow for 
some minutes, and then for a while it flowed much more slowly. This irregu- 
larity of secretion was probably in large measure due to unusual traction upon 
the bile-duct and liver during the introduction of the cannula, which in this case 
was much more difficult than usual. We have repeatedly observed that unless 
this part of the preliminary operation be conducted so as to very slightly disturb 
the bile-duct and its surroundings, the biliary secretion is rendered irregular. 
Nevertheless it is evident that in this case the euonymin stimulated the liver. 
