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PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 173 
TABLE XII : 
Secretion of Bile per Kilo- 
gramme of Body-weight 
i i er hour. 
Euonymin. Total Dose in Grains, Grains Bape aoe P 
| 
Before. | After. 
a | 
Experiment 27, , 5 with bile, 0:21 0:07 ce. 0°46 ce. 
- 28, : tae 3 0:26 0°25 cc. 0°47 ce. 
Results of Experiments with Euonymin.—1. Five grains of euonymin, when 
mixed with a small quantity of bile and water, and placed in the duodenum, 
powerfully stimulated the liver. 2. Coincident with the marked action on the 
liver there was only a slight increase of intestinal secretion. 
Experiments with Euonymin on Man.—In consequence of the powerful 
stimulation of the liver produced by euonymin in the above experiments, we 
were induced to make observations with it on the human subject in cases of 
biliousness, and we found the remedy of such value that it will, in consequence 
of these experiments, doubtless ere long be generally employed as a hepatic 
stimulant. Two grains made into a pill with conserve of roses, and taken at 
night, is a fair average dose for a man, though as much as five grains may be 
taken. A dose of two grains produces no sickness, headache, or other dis- 
agreeable sensation, and leaves no depression. But it must be remembered 
that while euonymin is a powerful hepatic, it is a feeble intestinal stimulant, 
and therefore it is well to follow it in the morning with some intestinal stimu- 
lant, such as two or three ounces Piillna water, or some other saline aperient. 
We are convinced from many observations that euonymin is particularly suited 
for cases in which the liver requires to be frequently stimulated. ) 
ACTION OF ReEsINA [RIDIS or “ [RIDIN.” 
The root of the Lis versicolor, or American Blue Flag, is said by Woop 
and Bacus (Op. x. p. 487) to possess cathartic, emetic, and diuretic properties. 
The American “Eclectics ” have used, under the name of iridin or irisin, an 
oleo-resin prepared in the same way as euonymin (p. 170). The dose of this is 
1-5 grains as a purgative. -“It is thought to unite cholagogue and diuretic 
with aperient. properties ” (Woop. and Bacue, doc. cit.).-.-An-anonymous writer 
in the Lancet (August 30, 1862) states that “it is gentler in its action than 
VOL. XXIX. PART I. 2Qy 
