PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 175 
Necropsy.—Stomach normal. There. was increased vascularity of the 
mucous membrane of nearly the whole length of the small intestine. The 
redness was not very marked, but it was greater than in the previous experi- 
ment. There was decided purgation, the small intestine containing 87 cc. of 
fluid with abundant mucous 
flocculi. 
Results of Experiments with 
Tridin.—1. Five grains of iridin 
when mixed with a little bile 
and water and placed in the 
duodenum very powerfully 
stimulated the liver. It is not Fig. 30.—Secretion of bile before and after iridin. 2ce. bile anl 2 ce. 
water injected into the duodenum at >. 5 grains iridin in the 
so powerful as large doses same Auid injected. at. 
(four grains) of podophyllin, 
we 
ne 
SS 
~ 
but it is more powerful than amik: get 
i i xperiment 30. 
euonymin, as is shown by the |__ bt Dat Divs ocd > elaine 
amount of bile secreted per Pe coms | Secretion of bile | nh I eaonetion of bile 
; *Secre of bile} per kilogramme || Secreti i r kilogre 
kilogramme of dog; the hourly | __ per 1s”. a dog: per | eer IB aaa 
coefficients of secretion for | pap ieeation | ple eases 
. . | 7, al = $$ $$$ 
the two euonymin experiments ee | A 
being 0°4789 cc.and0-4678cce., gs we 
whereas in the iridin experi- | 95; 0-8 
0°25 | 0-4 
ments they are 0°537 cc. and ar | ke 
Ze ‘00 
0-638 cc. respectively. The bars 0°6 | 
. . . 0 25 0°35 | 
high coefficient in the second Ws ] 0-7 
i. 3 0-25 0°166 ve. 0:85 
iridin experiment probably re- 0-25 0°9 
: 0-2 0°8 
sulted from a much smaller re 0°85 OreBaice, 
. 4 0:9 
dog getting the same dose as Seluaee og | 0-7 
; : | 0-2 Gzp.:) | 
in the first experiment, the 
smaller liver being thereby 
stimulated to do a proportionally greater amount of work. 2. Iridin is also a 
decided stimulant of the intestinal glands. Judging from these experiments, its 
irritant effects on the intestinal mucous membrane are decidedly less than 
those of podophyllin, while the purgative effects are greater than in the case 
of euonymin. The statement of the writer in the Lancet (above quoted) that 
in man “it is gentler in its action than podophyllin ” is fully supported by these 
experiments. 
