PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 177 
“ Eclectics” as a cholagogue and tonic. As this remedy is now a good deal 
employed in the case of children, it seemed desirable to obtain more precise 
information regarding its mode of action. The dose for a man is 3-3 grains 
three or four times daily. 
Experiment 31. Dog that had fasted eighteen hours. Weight 20-4 kilo- 
grammes (fig. 31).—3 cc. bile and 3 cc. water injected into the duodenum at 0. 
6 grains leptandria in the same fluid injected at ¢. 12 grains leptandria in 
2 cc. rectified spirit and 8 cc. water injected at e’. 
Experiment 31. Experiment 32. 
Secretion Secretion 
Secretion | of bile per Secretion | of bile per 
of bile per | kilogramme | of bile per | kilogramme 
15”: of dog: per 15”. of dog: per 
hour. hour. 
| 
ce. ce. 
0°8 0°35 
0°85 0°2 
0°95 0°25 
0°85 0°3 ) 
b a a 00839 cc. Fig. 31.—Secretion of bile before and after leptandria. 
; j 3 ce. bile and 8 cc. water injected into the duodenum 
1°2 0°191 ce. err Te at b. 6 grains leptandria in the same fluid injected 
0°95 0°55 ate. 12 grains leptandria in 2 cc. rectified spirit and 
x 0°95 ae 8 ce. water injected at e’. 
1°4 0°35 
1°3 0°55 
1°45 e —— 
1°45 ; 0°4 
1°35 he 272 cc. 0°55 
1°3 0°55 
1:2 0°5 
1:2 e” —— 
e —— 0°5 
1°45 07 
1°3 0°85 
1°45 ; 1:2 
15 lo 274 ce. 0-9 
1°35 0°9 
1°2 1:05 
El 1°0 
1°4 1°05 ‘ Pan 
1°25 0°95 ; Fie, 32.6 grains leptandria in 4 cc. water injected into 
12 11 le eteier *" the duodenum ie e 1% cc. bile and 8 cc. water 
1°05 injected at ec’. 12 grains leptandria in the same fluid 
injected at e”. 
Experiment 32. Dog that had fasted eighteen hours. Weight 13:1 kilo- 
grammes (fig. 32).—6 grains leptandria in 4 cc. water injected into the duo- 
denum at ¢. 14 ce. bile and 3 cc. water injected ate’. 12 grains leptandria in 
the same fluid injected at ¢”. 
Necropsy.—Slightly increased vascularity of the mucous membrane of the 
upper half of the small intestine. There was slight purgation ;—the upper half 
of the small intestine containing 37 cc. of a viscous fluid. 
VOL. XXIX. PART I. 22 
