178 PROFESSOR RUTHERFORD ON THE 
TABLE XV. 
‘ = [ay or meses s 
Secretion of Bile per Kilo- 
gramme of Body-weight 
Grai Kil per hour, 
Leptandria. Total Dose in Grains. “ai tederaahe 
Before. After, 
Experiment 31, . 18 with bile, 0°88 0191cc. | 0:274 ce. 
~ 32, =| 18 > 11 0083 ce. | 0°316 ce, 
TABLE X VI.—Composition of the Bile before and after Leptandria, 
Experiment 33. Before. After. 
Water, ‘ ‘ ‘ , ‘ ; ; ; ; : 91°34 91°41 
Bile-acids, pigments, cholesterin, fats, : 5 J : 6°64 6°60 
Mucus, ; ; ; a ; : : ‘ ‘ : 0:95 0:92 
Ash,» ; i : ; : ‘ ; , ; : 1:07 1:07 
100:00 100-00 
Velocity of secretion per half hour, : ; 3 : iL-2%cc: 2'5 ce. 
It appears from this analysis that the bile secreted under the influence of 
leptandria retained its normal composition. 
Results of Experiments with Leptandria.—Leptandria is a feeble hepatic 
and intestinal stimulant. Notwithstanding the large doses employed, the 
hourly coefficient of secretion did not rise above 0°316 cc. The bile has the 
normal composition. As in the case of other resinous matters, the absence of 
the biliary solvent from the duodenum greatly lessens the effect (Experi- 
ment 32). 
ACTION OF RESINA SANGUINARLIA, OR “ SANGUINARIN.” 
Dr Woop (Op. xi. p. 367) states that, “although the Sanguinaria cana- 
densis has been used more or less for so many years, we are still without any 
really definite knowledge of its action. Little or nothing has been added to 
our knowledge since the papers by Dr TuLLy in 1830, who stated that when 
given in small repeated doses it acts as a very decided cholagogue ; and more 
