PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 179 
recently it has been affirmed that it is also a stimulating expectorant. 
In full doses it is certainly a harsh emetic, and in overdoses, according to 
TuLLy, it produces with the vomiting, burning at the stomach, faintness, 
vertigo, dimness of vision, general. insensibility, coldness, extreme reduc- 
tion of the force and frequency of the pulse, great prostration of the muscular 
strength, and sometimes a convulsive rigidity of the limbs.” Dr Woop 
states that he has never known of its employment except as a stimu- 
lant expectorant in obstinate 
bronchitis. Dr MoTHERSHEAD, 
of Indianapolis (quoted in Op. 
x. p. 741) however “speaks in 
the strongest terms of its effi- 
cacy as an excitant of the liver, 
when given in alterative doses.” 
On the other hand, Professor 
Tuomas of Philadelphia (quoted 
in Op. x. p. 742), found the 
active principle sanguinarina to 
“have no effect of any kind 
directly on the liver” of man. 
* Sanguinarin” is, however, re- 
commended by the American 
“ Eclectics ” in doses of 1-1 
grain as a hepatic alterative. 
Fig. 33,—Secretion of bile before and after sanguinarin,. 2 ce. bile 
and 2°5 ce, water injected into the duodenum at 6, 1 grain 
sanguinarin in the same fluid injected ats, 2 grains sanguin- 
arin in the same fluid injected at s’. 
Experiment 33. | 
The substance employed in the Secretion Secretion 
: - 6 F Secretion | of bile per Secretion of bile per 
following experiments 1s a resin of bile per | kilogramme of bile per kilogramme 
: 15”. | of dog: per 15”. of dog: per 
prepared in the same manner hour. hour. 
as euonymin (see p. 170). | 
a8 ‘ ee. ce. 
Experiment 33. Dog that oe 1-15 
had fasted seventeen hours. ee id 
Weight 27:7 kilogammes (fig. A paarete nee! 
33).—2 cc. bileand 2°5 cc. water | ae ae 
injected into the duodenum at ie a an 
%. 1 grain sanguinarin in the ae ae 5 
same fluid injected at s, 2 1-0 2-2 
: : age s 2°2 
grains sanguinarin in the same 1-15 2-2 
. ape 1-12) 2:0 
fluid injected at s’. 1-0 | 
Nercrorsy.—Mucous mem- 
brane of upper two-thirds of small intestine was of a clear claret colour, 
here and there it was marked by brownish patches of a size varying from that 
of a sixpence to that of a half-crown. 
There were 35 ce. of a thick brown fluid 
