PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 181 
TasLtE X VII.—Composition of Bile before and after Sanguinarin. 
Experiment 33. Before. 
Water, ‘ ’ ; d : : : : x . 90:09 
Bile-acids, pigments, cholesterin, fats, . Sint ee 3 ‘ 7°38 
Mucus, : : i : : : : . ; é 1:04 
Ash, . : 5 : : , : : 5 : ” 1:49 
100-00 10000 
as | 
Velocity of secretion per half hour, . : : : ; 2:4 ce, 4:25 ce: | 
It appears from this analysis that under the influence of sanguinarin the 
bile becomes more watery, nevertheless the velocity of secretion having been 
nearly doubled by this agent, it is evident that the liver secreted more biliary 
matter. 
Results of Experiments with Sanguinarin.—1. In one experiment three 
grains, in another experiment one grain, of sanguinarin when mixed with a 
small quantity of bile and water and placed in the duodenum powerfully 
stimulated the liver. 2. It rendered the bile more watery, nevertheless it 
caused the liver to secrete more biliary matter in a given time, 3. The 
secretion of the intestinal glands was slightly increased by these doses. These 
results show that the statements of TuLty and MoTHERSHEAD ought not 
to be treated with indifference and neglect, as they appear to be, in practical 
medicine. 
ACTION OF IPECACUAN. 
As is well known, ipecacuan is regarded as almost a specific remedy in 
certain cases of dysentery. It is stated that it gives rise to evacuations con- 
taining a large quantity of bile. The manner in which it does this is not 
definitely known. Some maintain that it permits of biliary discharge by 
relieving spasm of the bile-ducts. The following experiments, undertaken at 
the desire of Sir Ropert Curistison, prove beyond a doubt that this substance 
is a powerful stimulant of the hepatic secreting apparatus. The maximum 
dose for a man is 60 grains. 
Experiment 35. Dog that had fasted eighteen hours. Weight 15 kilo- 
grammes (fig. 35).—2 cc. bile and 3 cc. water injected into the duodenum at 3. 
60 grains ipecacuan powder in the same fluid injected at 7. 
Nercropsy.—The ipecacuan had extended along the upper half of the small 
VOL. XXIX. PART I. 3A 
