PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 183 
Experiment 36.. Dog that had fasted eighteen hours. .Weight 27:2 kilo- 
grammes (fig. 36).—2 ce. bile and 5 ce. water injected into the duodenum at b. 
The same fluid with 60 grains ipecacuan powder injected at 7. 
Necropsy.—Stomach normal, The ipecacuan extended along the upper 
two-thirds of the small intestine, the mucous membrane of which exhibited a 
slight increase of vascularity, and was covered with thick mucus, but there was 
no purgation. 
Even in much smaller doses, however, ipecacuan excites the liver, as is 
shown by the two following experiments. 
Experiment 37. Dog that had fasted eighteen hours, Weight 61 kilo- 
grammes (fig. 37).—1°5 cc. bile and 2 cc. water injected into the duodenum at 0. 
The same fluid with 3 grains of ipecacuan powder injected at 2. 
‘Experiment 37. 
Secretion Sectetion 
Secretion | of bile per | Secretion | of bile per 
of bile per| kilogramme | of bile per | kilogramme 
15”, of dog: per 15”. of dog : per 
hour. hour. 
ec." 4—— 
0°2 0°4 
0°2 0°25 
0°2 0°3 
0°25 0°7 
0°3 07 : Fig. 37. Secretion of bile bef d after i 5 ee 
; é 0°385 ce. » 37. of bile before and after ipecacuan. 1°65 ce. 
0°25 0°45 ” pile and 2 cc. water injected into the duodenum at d. 
0°3 0°5 The same fluid with 3 grains of ipecacuan powder injected 
0°3 07 at 7. 
0'2 07 
b — 0°35 
0°25 0°45 
0°25 4 0°5 
03 0°18 ce. 0-45 
0°3 0°4 
Experiment 38. 
Secretion Secretion 
Secretion | of bile per | Secretion | of bile per 
of bile per | kilogramme | of bile per} kilogramme 
15”. of dog: per 15”. of dog: per 
hour. hour. 
ce. 0°9 
0°3 0°6 
0:2 06 
0°25 09 
ea me bose ce. 
b — 1°15 
0°3 0°55 
bs 0186 ce. ee Fig. 38.—Secretion of bile before and after ipecacuan. 17°5 ce. 
0:3 0°35 bile and 2 cc. water injected into duodenum at b. 3 
a 0-4 grains ipecacuan powder in the same fluid injected at 7 
0°45 0°3 
0°6 
Necropsy.—Thick mucus covering the mucous membrane of upper fourth 
ef small intestine. No purgation. 
