PHYSIOLOGICAL ACTIONS OF DRUGS ON. THE SECRETION OF BILE. 187 
Experiment 40. Dog that had fasted sixteen hours. Weight 16:3 kilo- 
grammes (fig. 40),—3 ce. bile and 3 cc. water injected into the duodenum at 0. 
The same with 7 grains colocynth injected atc. The same repeated at ¢’. 
‘Necropsy.—There was increased vascularity throughout the whole length 
of the mucous membrane of the small intestine, especially marked in the upper 
part. There was considerable evidence of purgation. 
TABLE XXI. 
| Secretion of Bile per Kilo- 
gramme of Body-weight 
¢ Kil per hour. 
Colocynth. Total Dose in Grains. Bea eee 
Before. | After. 
| | 
Experiment 39, . 14 with bile, | we oom. al O29 ec. |e O'45.cc, 
7 () e 7 r | 0-4 | O-16 ce. 0:27 cc. 
In Experiment 40, the pulse became very weak towards the close of the 
experiment, and it may be that this weakness rendered the effect of the colo- 
cynth upon the liver less than it otherwise might have been. Be this as it may, 
we did not think it necessary to perform another experiment, for the first 
experiment with this substance may be regarded as sufficient. 
TABLE X XII.—Composition of the Bile before and es Colocynth. 
Experiment 39. | Before. | After. | 
ee ee 94:13 
Bile-acids, pigments, cholesterin, fats, : | 549 4:70 
SS a a 0-90 0°70 
Ash, | 0°62 0°47 
100-00 10000 
Velocity of secretion per half hour, . | 34 ce, 6°35 ee 
| 
The analysis shows that colocynth renders the bile more watery, but it is 
evident from the increased velocity of secretion that it compels the liver to 
secrete more of the biliary solids proper. 
Results of Experiments with Colocynth—Colocynth is, in large doses, a 
powerful-hepatic, as well as intestinal stimulant. Though rendering the bile 
more watery, it increases the secretion of biliary matter. 
