“same fluid injected at 7, 7’, 
PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETIONS OF BILE. 189 
Necropsy.—The jalap had extended along about four-fifths of the small 
intestine, the mucous membrane of which was more vascular than usual, 
especially at the lower part of the duodenum. The purgative effect was con- 
siderable—there being 64 cc. of fluid in the intestine. The fluid was of a 
very watery character. 
Experiment 42. Dog that had fasted twenty-two hours. Weight 12°3 kilo- 
erammes (fig. 42).—2 ce. 
bile and 3 cc. water injected 
into duodenum at 6. 20 
grains jalap powder in the 
and 7”. 
The fall of the bile-secre- 
tion towards the close of the 
experiment is only another Fig. 42.—Secretion of bile before and after jalap. 2 cc. bile and 3 
; 2 ee. water injected into duodenum at 6. 20 grains jalap powder 
illustration of the fact often a Ge anti Wiad tniecied at? 4" and 7”. 
witnessed by us—that severe a 
. ot cee Experiment 42. 
purgation diminishes the se- | 
cretion of bile. Secretion | Secretion 
Secretion of bile per Secretion of bile per 
Necropsy.—20 cc. of of bile per | kilogramme || of bile per | kilogramme | 
: aes : 15”. of dog: per | 15”. | of dog : per 
fluid had been injected into hate hour. | 
the duodenum, much of fi a r ie 
i bly been 0-6 | 1-05 
which had probably . 0°55 | 1-05 0°357 ce. 
absorbed ; the small intes- aS 095 | 
. . 4 x | 
tine, however, contained in 40° 1°05 
. 5 . aaa | oy) 
its upper third 117 cc. of 05 fou Se Se 
; f 0°6 0-7 
watery fluid, showing that 0°6 0°5 
° ° j-— 0°75 
a profuse purgative action 0°65 0°75 | 
‘ : 0°85 0°25 
was taking place. The jalap 0°8 0°25 
0°6 0°25 
had extended along only a 0-9 0-35 ) 
° é é pee 2s “4 
third of the small intestine. I eas pone ce. 
The analysis shows that oe Sie ae IK 
although jalap renders the 
bile more watery, it so increases the velocity of secretion that more biliary 
matter is secreted in a given time. 
Results of Experiments with Jalap—1. Jalap is a hepatic stimulant of con- 
siderable power. It renders the bile more watery, but at the same time increases 
the secretion of biliary matter. 2. Its effect on the liver is however far less 
notable than its effects on the intestinal glands. Its hydragogue cathartic 
effects were fully manifested in these experiments. 
VOL. XXIX. PART I. 3 C 
