PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 191 
four hours, adding 25 cc. water (“ British Pharmacopeceia’). The dose for a 
man is from 5 to 20 minims. 
The employment of this substance in hepatic disorder was first recommended 
by Dr Scorr of Bombay, who used it largely in congestion of the liver. It was 
administered as a foot-bath, and also internally. Its effects, however, were by 
some held to be so doubtful, that its use appears to have been abandoned for a 
time (CHRISTISON, Op. xii. p. 41). ANNESLEY, Martin, and others—experienced 
in the diseases of India—have, however, supported the opinion held by Scort. 
Woop (Op. xi. p. 88) maintains, from 
his own observation, that it increases 
the flow of the bile. 0-5 
Experiment 44. A small dog 
(weight not ascertained) that had 
fasted seventeen hours (fig. 44).—20 cc. 1 
water injected into duodenum ata, The Fig. 44.—Secretion of bile before and after nitro-hydro- 
same with 20 minims dilute nitro-hydro- The Gane ee ao miilne dilate Bai ohydre 
fs Wee chloric acid injected at 6, c, d, and e. 
chloric acid injected at 0, ¢, d, and e, 
Necropsy.—The duodenal mucous membrane was slightly congested. 
There was no evidence of purgation, 
Experiment 444, Dog that had fasted seventeeen hours. Weight 17:7 
nN 
rs 
si 
Experiment 44a. 
Secretion 
Secretion of bile per | 
of bile per kilogramme | 
15y. of dog: per 
hour. | 
ce. 
0°55 
ve boa ce, 
0°65 
a ——— 
1:00 
0:95 
1:05 
1:10 
1°40 
1°45 
ileayty; 
1°60 
1°40 
1°50 
2°20 0°392 ce. 
1°72 Fig. 444.—Secretion of bile before and after nitro- 
1°62 hydrochloric acid. 40 minims dilute nitro- 
1°45 hydrochloric acid in 8 cc. of water injected into 
a’ —— duodenum at a, and again at a’. 
1°50 
1:35 
0°95 
kilogrammes (fig, 444).—40 minims dilute nitro-hydrochloric acid in 8 ce. 
| water injected into duodenum at a, and again at @’. 
