192 PROFESSOR RUTHERFORD ON THE 
Necropsy.—There was slight congestion of the upper part of the small 
intestine to the extent of about 10 inches. In the duodenum the mucous 
membrane had a yellowish-grey appearance, as if it had been slightly corroded 
by an acid. There was no evidence of any purgative effect. 
Results of Experiments with Nitro-hydrochloric Acid.—The positive effect 
of the acid in Experiment 444 is in remarkable contrast to the negative result 
observed in Experiment 44. In consequence of the positive result in the former 
case, and seeing that it com- 
pletely agrees with observa- 
tions on man, we did not think 
it necessary to perform another 
experiment. In view of the : 
positive effect in 444, we do : 
not attach any importance to | 
the negative result of Experi- 
ment 44; for the animal was 
a small one, and in such cases 
we have found that undoubted 
cholagogues sometimes fail 
to act. It is proved, then, 
that dilute nitro-hydrochloric 
10 ce. 
The same with 120 grains 
(480 grains given in all). 
Fig. 45.—Secretion of bile before and after sodium chloride. 
water injected into duodenum at w. 
sodium chloride injected at's, s’, s”, s 
Uda 
Experiment 45. 
acid is a hepatic stimulant of 
considerable power. 
Secretion Secretion ACTION OF SODIUM CHLORIDE. 
Srrle ees i Wlocenty (cameras eieliofane Sodium chloride son Racal 
15”. of dog: per | Wa, of dog: per 
Hon: poe artic when given indoses of 120 
; | to 240 grains. Itis not stated 
1 | 1-90 t 0-308 am to be a cholagogue, but as it 
1°82 , 180 is contained in considerable 
oa i 135 | quantity in the mineral waters 
175 Nios ae 215 be —— of Carlsbad, Ems, Friedrich- 
i (|S 222 |S shall, that have a reputation 
” 1-70 rate ! in abnormal conditions of the 
ae Wik ee liver, we thought it desirable 
Paci re to test its action on this organ. 
ee eon ae Experiment 45. Dog that 
sihiag : had fasted eighteen hours. 
Weight 25 kilogrammes (fig. 
45).—10 cc. water injected into duodenum at w. The same with 120 grains 
sodium chloride injected at s, s’, x’, s’” (480 grains given in all). 
