PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 193 
_ Necropsy.—The small intestine contained 203 cc. of fluid, with numerous 
mucous flakes. As only 50 cc. of fluid had been injected, decided purgative 
action had taken place. The vascularity of the mucous membrane was slightly 
increased. 
Result of Experiment with Sodium Chloride.—Inasmuch as the first three 
doses of sodium chloride, amounting in the aggregate to 360 grains, produced 
scarcely any effect on the secretion of bile, it may be concluded that. this sub- 
stance is a very feeble hepatic stimulant. Another experiment did not appear 
to be required. 
ACTION OF SODIUM AND PoTASSIUM TARTRATE. 
Rochelle salt is well known as an intestinal stimulant, but its action on .the 
liver has not hitherto been pointed out. The dose for aman is 120 to 240 
grains. 
Experiment 46. Dog that had fasted seventeen hours. Weight 5:2 kilo- 
grammes (fig. 46).—10cc. water 1 
injected into duodenum at w. 
The same with 60 grains Ro- 
chelle salt injected at 7, 7’, 7”, 
and?” (240 grains given in all). 
No Necropsy. a 
Considering the small size .. 
y - mae Fig. 46.—Secretion of bile before and after tartrate of potash and soda. 
of this animal, the exciting 10 cc. water injected into duodenum at w. The same with 60 
: grains Rochelle salt injected at, 7’, 7’, 7” (240 grains given in all) 
effect of the salt on the liver = 
was very remarkable, the se- Bectnctac: | 
cretion of bile per kilogramme , : 
of body-weight CE hour being Secretion of Ae | Secretion of bien kilo. 
raised to 0°653 cc. The fall Meyer Is, | cme of | bile per 15”. | gramme of 
in the secretion towards the oh = oH Sskcamede 
close of the experiment was ce. | ce, 
doubtless owing to purgative wee ue 
action taking place. OB fon - "0-80 
Experiment 46a. — Dog are, Oy Sis lens ce. 
that had fasted twenty hours. aan aay J 
Weight 12:5 kilogrammes (fig. pk cue 
464).—3 cc. bile and 55 ce. ne lee) ie ge 
water heated to 37° C. injected 
_ into duodenum at d. The same with 463 grains Rochelle salt heated to 37° C. 
| Injected at 7. 
NeEcropsy.—Small intestine contained 130 cc. of a clear mucous fluid, | 
VOL. XXIX. PART I, 3D 
