PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 195 
ACTION OF SODIUM PHOSPHATE. 
Sodium phosphate is described in the text-books as a mild saline purgative; 
nothing being said about its action as a cholagogue. Professor STEPHENSON of 
Aberdeen (Op. xiii.), however, has found it specially useful for children when 
there is a deficiency of bile in the discharges. The dose as a purgative for a 
man is 120 to 480 grains. 
Experiment 47. Dog that had fasted twenty hours. Weight 26:9 kilo- ’ 
Experiment 47. 
Secretion of bile 
per kilogramme of 
dog: per hour. 
Secretion of bile 
per 15”, 
ce. 
2°05 
2°07 
1°90 ) 
1°90 5 
1°80 ‘i 278 ce. 
1°80 
25 
NNNNRFRReE 
EEE SOMOS sy 
NNT SSO 
prnrwnr 
me bd ND DD 
coouns 
2°30 
2°60 
lost. 
| 2°70 
1 2 3 4 5 6 7 | 2°80 
2°90 
Fig. 47.—Secretion of bile before and after sodium phosphate. 77 2°95 hou os 
grains in 15 ce. water injected into duodenum at s, and 124 grains 3°15 
in 25 cc. water injected at s’. 3°05 
. | 2°30 
2°57 
grammes (fig. 47).—77 grains in 15 cc. water injected into duodenum at s, and 
124 grains in 25 cc. water injected at s’. 
NeEcropsy.—Somewhat increased vascularity of mucous membrane of small 
intestine. Evidence of a very decided purgative effect: the contents of the 
_small intestine being of a very watery character. 
