PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 197 
into duodenum at }. 508 grains sodium sulphate, in the same fluid heated to 
37° C., injected at s. 
Experiment 48. Experiment 484A. 
1 
Secretion Secretion 
Secretion | of bile per | Secretion | of bile per 
of bile per | kilogramme | of bile per| kilogramme 
15” of dog: per 15”, of dog: per ne 
hour. hour. 
ce. ce. 0 
0°25 1:00 
0°25 0°95 1 2 3 4 5 
ah cee Fig. 48.—Secretion of bile before and after sodium sulphate. 
0°55 ‘hia 12 cc. water injected into duodenum at w. 60 grains 
0°50 0°95 sodium sulphate in 12 cc. water injected at s, and again at s’. 
0°50 0°107 ce. 1°05 0-251 ce. 
wo — 0°95 
0°55 1:00 
ess SS —— 
0°80 1:00 15 
1:00 110 | 
1:05 ty 1°05 | 
1°65 0'266 ce. 115 
1:50 1:25 
0°65 1°40 . 
1:00 1°45 
sf —— 1°50 
0°60 1°60 ’ 
1:30 1°55 0°388 ce. 05 
1:40 Oe 45 ay) 
1°50 0°279 ce. 1°55 
1:25 1°45 
1°35 0 
1°50 
rae 1 2 3 4 5 6 7 
1°35 Fig. 484.—Secretion of bile before and after sodium sulphate. 
3 ce. bile and 5 ce. water, heated to 37° C., injected into 
duodenum at 6. 508 grains sodium sulphate, in the same 
fluid heated to 37° C., injected at s. 
Necropsy.—Mucous membrane of whole length of small intestine slightly 
reddened. The small intestine contained 147 cc. of clear fluid with greenish 
flakes, thus affording evidence of a decided purgative effect. 
TABLE XX VII. 
Secretion of Bile per Kilo- 
gramme of Body-weight 
per hour. 
p . Asse Grains per Kilogramme | 
Sodium Sulphate. Total Dose in Grains. | of Bo dy-weight. | 
| | 
{ Before. | After. 
Experiment 48, : 120 6-1 | (O7O%ee: 0°25 ce. 
ae 508 | 3273 (25 ce. 0°38 ce. 
VOL. XXIX. PART I. 0 E 
