PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 199 
flakes. The mucous membrane exhibited increased vascularity with small 
ecchymoses in its upper fourth. 
In this case, therefore, this substance irritated the intestine and produced 
purgation, but did not excite the liver. It was decided to give in the next case 
a larger dose. 
Experiment 49a. Large dog that had fasted seventeen hours. Weight not 
recorded (fig. 494).—23 cc. bile and 35 cc. water injected into duodenum at 4, 
the same with 142 grains potassium sulphate injected at s, and again at s’. 
4 
Experiment 49a. 
Secretion 
of bile per 
15”. 
2:20 Fig. 494.—Secretion of bile before and after potassium sulphate. 2% cc. 
2:25 bile and 35 cc. water injected into duodenum at b, the same with 142 
2:05 grains potassium sulphate injected at s, and again at s’. 
Necropsy.—Small intestine contained 148 cc. watery fluid. The vascularity 
_ of the mucous membrane in the whole length of the small intestine was slightly 
increased. 
There being in this case evidence of a slight increase of the biliary secretion, 
another experiment was thought desirable. 
