200 PROFESSOR RUTHERFORD ON THE 
Experiment 498. Dog that had fasted seventeen hours. Weight 21°5 kilo- 
grammes (fig. 498).—232 grains potassium sulphate dissolved in 32 cc. water 
at 37° C. and injected into duodenum at p. 
Experiment 49s. 
Secretion 
Secretion of bile per 
of bile per | kilogramme 
15”, of dog: per 
hour. 
ce. 
1°80 
1:90 
1:70 
5 1°65 . 
2 1°65 | 0°316 ce. 
1:70 
p 
1°80 
15 1°70 
1°90 
1°80 
1°90 
‘ 2°05 
2°07 
2°10 
2°25 
2°37 
05 2°45 
2°40 
2°45 
2°50 
2°47 
2°55 
- 2°55 ; 
1 2 3 4 5 6 7 8 9°57 he 47 ce. 
2°45 
Fig. 49.—Secretion of bile before and after 232 grains potassium sulphate 2°40 
dissolved in 32 ce. water at 37° C., and injected into duodenum at p. 2°30 
2°40 
2°40 
2°20 f 
1:95 ho 352 ce. 
1°29 
NeEcropsy.—Increased vascularity of mucous membrane in whole length of 
small intestine. The small intestine contained 90 cc. clear brownish fluid, 
with numerous mucous flakes. There was, therefore, evidence of considerable 
purgative action. 
Results of Experiments with Potassium Sulphate-—Experiment 498 shows 
that potassium sulphate is undoubtedly a hepatic stimulant. The dose of 232 
grains, given in this case to a full-sized dog, was just the maximum dose for a 
man. ‘The negative effect of 124 grains in Experiment 49, and the slight effect 
of 142 grains twice repeated in Experiment 49a, show that this substance is 
uncertain in its action on the liver. Regarding its action on the intestinal 
glands, however, there was no uncertainty, for its purgative effect was pro- 
nounced in all the three experiments. Possibly, the sparing solubility of the 
salt may render its absorption into the portal vein uncertain. The bile given 
along with the salt in Experiments 49 and 49a had probably nothing whatever 
