PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 201 
to do with the result. The result of Experiment 498 completely supports Dr 
WADE'’s opinion, that potassium sulphate is a cholagogue. Indeed, the amount 
of bile secreted per kilogramme of body-weight under its influence in that 
experiment was greater than in either of the experiments with sodium sulphate 
(48 and 484). The apparent uncertainty, however, in the action of potassium 
sulphate must not be lost sight of. 
ACTION OF SopIuM BICARBONATE. 
The previously mentioned salts of sodium and potassium having all been 
found to have some action on the liver, it was determined to try the effect of 
the bicarbonates. 
Experiment 50. Dog that had fasted eighteen hours. Weight 16:3. kilo- 
grammes (fig. 50).— 
5cc. water and 2 cc. 
bile were injected 
into the duodenum 
at b (a needless pre- 
caution); 31 grains 
of sodium bicarbon- 0; 
ate in the same fluid 
were injected at s, s’, 
and s”’; and 124 ; ; F ; : , E : : 
grains in 15 cc water 
Fig. 50.—Secretion of bile before and after sodium bicarbonate. 5 cc. water and 
and 2 cc. bile were 2 ec. bile injected into the duodenum at 6. The same with 31 grains sodium 
™ my bicarbonate injected at s,s’ and s”. 15cc. water with 2 ce. bile and 124 
injected tes ye 2h7 grains sodium bicarbonate injected at s’”. 
grains being given 
in all. Only after the last dose did the secretion of bile begin to rise 
slightly. 
Necropsy.—The vascularity of the mucous membrane of the small intestine 
was slightly increased. The viscus contained 60 cc. of a greenish mucous 
fluid. 
Experiment 504.—Dog that had fasted eighteen hours. Weight 19-9 kilo- 
grammes (fig. 50A).—5 cc. of water and 2:dcc. of bile were injected into the 
duodenum at } (a needless precaution), and the same fluid, with 64 grains of 
sodium bicarbonate, was injected at s, s’, and s’—192 grains being given in all. 
The secretion of bile rose slightly after each dose. 
Result of Experiments with Sodium Bicarbonate.—In Experiment 50, the 
hourly coefficient of secretion per kilogramme of body-weight during the first 
hour was 0°294 cc.; during the seventh hour, it was 0:287 cc.; and during the 
VOL. XXIX. PART I. 3 F 
