PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 203 
Result of Experiment with Potassium Bicarbonate.— Before the alkaline salt 
was given, the hourly coefficient of secretion per kilogramme of body-weight 
was 0°238 cc. ; and, after 201 grains had been given, it rose to 0°384 cc. Seeing 
that 31 grains produced no effect, it may be safely assumed that, when a dose 
_ of 10 or 15 grains is taken by man, his biliary secretion is not sensibly affected. 
Fig. 51.—Secretion of bile before and after potassium bicarbonate. 31 grains in 8 cc. 
water injected into duodenum at p, p’, and p”. 108 grains in 8 cc. water in- 
UL 
jected at p”. 
| Experiment 51. 
Secretion Secretion 
Secretion of bile per Secretion of bile per 
of bile per | kilogramme || of bile per | kilogramme 
| 15”. of dog : per aE of dog: per 
| hour. hour. 
ce. ce. 
1°30 1°30 
1 85 yl eer, 
1°10 1°45 
115 J 1°40 
1-20 ho 288 cc. 1°45 
1°15 1°50 
Oo 1°50 
1°20 1°60 
115 1°50 
1°15 1°67 
p—— 1°70 
1°25 1°50 
1°30 1°80 
| 4 \ mae hoa ce. 
| 0287 ce. 
1°50 1:90 
1°30 1:70 
‘a 1:40 
1°25 1°45 
1:30 1:30 
ACTION OF IODIDE OF POTASSIUM. 
Potassium iodide is sometimes. administered in hepatic affections, in the 
hope that it may produce an ‘“‘alterative” effect. On that account it seemed 
desirable to ascertain whether or not it affects the biliary secretion. 
