PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 205 
by Professor FRASER, this agent excites the salivary, intestinal, and lachrymal 
glands; and at his request we performed the following experiments on the 
liver. The extract of Calabar bean of the “ British Pharmacopceia” was the 
preparation employed, the maximum dose of which for the human subject is a 
quarter of a grain. 
Experiment 53. Dog that had fasted eighteen hours. Weight 26°7 kilo- 
grammes (fig. 53).—1 
grain extract of Calabar 
bean triturated with half 
cc. of bile, half cc. of rec- 
tified spirit, and 5 cc. of 
water, was injected into 
the duodenum at ¢, and 
the same dose was given 
again at c’. The in- 
creased secretion of bile 
was decided and pro- 
longed after the second 
dose. The bile and al- 
cohol were employed 
merely to promote ab- 
sorption of the active 
principle, and it may be 
safely assumed that none 
of the effect was directly 
due to either, for it has 
been already stated that 
mece. or 3 cc. of bile 
introduced into the duo- 
denum does not notably 
affect the biliary secre- 
tion; and it will be 
shown that a much 
larger quantity of alco- 
hol than was given in 
this case has also no 
effect (Experiments 73 
and 74). 
Although the anta- 
gonism between atropia 
Fig. 53.—Secretion of bile before and after Calabar bean and atropia. 1 
grain extract Calabar bean with 4 cc. bile, 4 cc. rectified spirit, and 5 cc. 
water, injected into duodenum at ¢, and again at c’; $ths grain atropia 
sulphate injected into duodenum at a; #thsgrain into jugular vein at a’. 
Experiment 53. 
Secretion Secretion 
Secretion of bile per Secretion of bile per 
of bile per | kilogramme || of bile per | kilogramme 
15% of dog : per 15”, of dog : per 
hour. hour. 
ce. ce | 
0°70 2°50 
He 2°40 ) 
6 2°15 
0°55 | 2°40 Vs 365 cc. 
0°70 ; 2°20 
0°60 \ 0098 ce. 1°75 
0°80 2°00 
¢—— a —— 
0°75 1:90 
0°55 1°80 
0°85 1°90 
1°10 1°65 | 
1°60 a 
1:30 1:20 
1°35 0°60 
0°90 0:90 ) 
0°75 0°50 : 
aa ' 0-70 ‘S 098 ce. 
2°05 
and physostigma has been abundantly proved by Fraser, ARNSTEIN, HEIDEN- 
VOL, XXIX. PART I. 
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