PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 209 
Ten grains of acetate of lead, dissolved in 20 cc. of tepid water, were in- 
jected into the duodenum at /, without producing any notable effect. 
Having, in other experiments—mentioned in the sequel—discovered that 
the alkaline salts of benzoic acid are powerful hepatic stimulants, we suspected 
Experiment 54. 
Secretion 
Secretion of bile per 
of bile per | kilogramme 
15.” of dog: per 
hour. 
Fig. 54.—Secretion of bile before and after atropia sulphate, lead acetate, and ; 
sodium salicylate. 4 grain of atropia sulphate in 20 minims of water in- 
jected into jugular vein a, a’, vw’, and a@’”; 1 grain injected into vein at a”; 1°10 
10 grains of lead acetate in 20 cc. of warm water injected into the duodenum 
at 7; 25 grains of sodium salicylate in 25 cc. of water injected into the 0°95 
duodenum at s. 
0°260 ce. 
(=) 
ive) 
Or 
% 7 
2°75 
2°90 foo ee! 
that the alkaline salts of salicylic acid would be found to have a similar action. 
Accordingly, twenty-five grains of sodium salicylate, dissolved in 25 cc. of 
water, were injected into the duodenum, and within half an hour a very rapid 
secretion of bile had begun; and this, notwithstanding the previous administra- 
tion of lead acetate and three grains of atropia sulphate. 
Result of Experiments with Atropia.—Atropia sulphate does not paralyse 
the hepatic cells, neither does it appear to excite them. Whether or not it 
VOL. XXIX. PART I, 3H 
