PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 211 
duodenum at b. This producing no perceptible effect on the secretion, five 
grains of menispermin were triturated with the same amount of bile and water, 
and injected into the duodenum at m; and the same dose was repeated at m’. 
The secretion remaining unaffected, ten grains with bile and water, as before, 
Experiment 55. 
- Secretion of bile a Secretion of bile 
“aoe per kilogramme aes as per kilogramme 
. rr ia of dog: per || ° 1 5” P of dog : per 
hour. hour. 
| a — 
ce. ce. 
1.65 1°40 
2°00 1°35 0233 ce.| 
Bae |; W811. ce. peer 
1°55 1°50 
m —— 1°65 
1°45 1°95 
ma ee 0°394 ce. 
1:25 2°05 
1:05 1:95 
1°30 0°233 ce. 175 
Fig. 55. Secretion of bile before and after menispermin 
and baptisin. 7 grains of menispermin in 1°5 cc. of 
bile and 3 cc. of water injected into the duodenum 
at m; 7 grains of baptisin in 2 ce. of bile and 3 ce. of 
water injected at b. 
Experiment 56. 
Secretion Sain | Secretion ae ee a 
sf ag Per | kilogramme of || o me Per | kilogramme of 
; dog : per hour. | : dog : per hour. 
| | 
ce. | ce, 
1°4 || m’ —— 
1-4 | 1°80 
13 l 1°25 
at Lite 
— | 1°25 f 
1-4 ie ce. | 130 OiS1D Ce 
1°3 i 1:25 
1°25 a" —— R 4 q 
| i — 1:30 Fig. 56. Secretion of bile before and after menispermin. 
1°25 | 115 2 ce. of bile and water injected into the duodenum at 
1:20 | 1:16 b; the same, with 5 grains of menispermin, injected 
1°25 1:25 y at m, and again at m’; the same, with 10 grains in- 
} 1°30 1:05 0'287 ce. jected at m’”. 
: 115 , 
) 1°05 
| were injected at m’. The bile-secretion was remarkably constant, and the 
experiment clearly proyed that this substance, even in large doses, does not 
excite the liver; and that the rise of secretion observed in Experiment 55 
