214 PROFESSOR RUTHERFORD ON THE 
employed by us was a substance termed “ phytolaccin,” prepared from the root, 
of the plant by Ketru & Co. of New York, after the same manner as meni- 
spermin (page 210). The dose for a man is from one to three grains. The 
physiological actions of phytolacca have not hitherto been investigated. 
Experiment 58. Dog that had fasted eighteen hours. Weight 31:1 kilo- 
grammes (fig. 58.)\—Two grains of phytolaccin triturated with 2 cc. of bile and 
4 cc. of water were injected into the duodenum at ». The subsequent excitement 
of the liver was unequivocal. When the increase of secretion was well declared, 
Experiment 58. 
Secretion as Secretion eee oie 
on Lie Per | kilogramme of us re Per | kilogramme of 
: dog: per hour. 5 dog: per honr. 
ce. evs t 
1:10 2°00 ; 
0°85 prep ak 0'244 ce. 
0-90. 1°80 
1°10 2°25 
1°30 ; a’ —— 
1-20 \ 144 ce. 1:90 
— 2°20 
1°45 2°30 
1°55 a!” —— 
1°65 2°40 
1°85 2°35 
1°85 |” —— ; 
. ' 1:90 2°35 \ 299 ce. 
Fig. 58.—Secretion of bile before and after phytolaccin and 1:90 0-244 2°30 
atropia. 2 grains of phytolaccin in 2 cc, of bile and |} 1:90 ote 
4 cc. of water injected into the duodenum at p; 1-10th | 
of a grain of atropia sulphate injected into the jugular 
vein at a, a’, a”, and a”. 
one-tenth of a grain of atropia sulphate dissolved in ten minims of water was 
injected into the jugular vein at a, and again at a’, a’, a”’—in all four-tenths 
of a grain; but the stimulating effect of the phytolaccin was not antagonised 
thereby. Had this experiment been performed after instead of before Experi- 
ment 53, a larger dose of atropia would have been given. Remembering the 
non-exciting effect of atropia on the liver, the high secretion at the close 
of the experiment may be safely referred to the continued action of the 
phytolaccin. 
Necropsy.—The duodenal mucous membrane was slightly reddened, but 
there was no evidence of purgative action worthy of mention. 
Experiment 59. Dog that had fasted seventeen hours. Weight 19:2 kilo- 
erammes (fig. 59).—Two cc. of bile and 2 cc. of water were injected into the 
duodenum at 4, and 2 grains of phytolaccin triturated with the same fluids 
were injected at py. A considerable increase of bile-secretion ensued. Owing 
to the high secretion previous to the administration of the drug, the result is 
less striking than in the preceding experiment ; yet, in this case, the coefficient 
