7 
that in Experiment 61 a dose relatively larger in proportion to the size of the 
animal than in Experiment 60 produced a smaller effect on the liver—seems — 
only explicable by the fact that the subject of the former experiment was, as 
already stated, in an abnormal condition. Altogether, hydrastin appears to be — 
a substance eminently worthy of the attention of the physician. 
21 
(96) 
PROFESSOR RUTHERFORD ON THE 
TABLE XXXI. 
Secretion of Bile per Kilo- 
gramme of Body-weight 
. . } b 
Hydrastin. Total Dose in Grains. pecans gan iy Baie 
Before. After. | 
Experiment 60, . 2 with bile, 0:077 0:23 cc. | 0386 ce. | 
n Giles 2 5 0:147 0°09 ce. | 0°323%ce 
ACTION OF RESINA JUGLANDIS OR “ JUGLANDIN.” 
The juglandin employed in the following experiment was not an alkaloid, but 
an impure resin prepared by Keira & Co. of New York, from the bark of the 
root of the butternut or white walnut (Juglans cinerea), after the same manner 
as menispermin (p. 210). Regarding the properties of the bark of the butter- 
nut, Woop and Bacue (Op. x., p. 492) state that it is a mild cathartic, operating 
without pain or irritation, and resembling rhubarb in the property of evacuating 
without debilitating the alimentary canal. It was much employed during the 
late American civil war by Dr Rusu and other army physicians. It is especially 
useful in habitual costiveness and dysentery. Nothing is stated regarding any 
influence on the liver. An extract of the bark is officinal in the United States. 
The dose of Kxrrn’s juglandin—the substance used in the following experiment 
—is from two to five grains. 
Experiment 62. Dog that had fasted eighteen hours. Weight 21:1 kilo- 
grammes (fig. 62).—Five grains of juglandin, triturated with 2 ce. of bile, 
2 cc. of rectified spirit, and 5 cc. of water, were injected into the duodenum at 
Jj, and the same dose was repeated at 7’. Both doses were followed by increased 
bile-secretion, which lasted four hours, and would probably have lasted even 
longer. ‘Twenty grains of sodium salicylate in 10 cc. of water were injected 
into a lower part of the small intestine at s, and speedily caused a much greater 
hepatic excitement. Before any drug was given, the coefficient of secretion 
was 0104 ce. of bile per kilogramme of body-weight per hour. After the first 
