PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 219 
dose, it rose to 0'286 cc., and after the second to 0°327, showing that juglandin 
is a hepatic stimulant of moderate power. Indeed, it occasions a coefficient 
Experiment 62. 
| 
Secretion of bile 
Secretion of bile | per kilogramme 
per 15”. of dog: per 
hour. 
Ge: 
0°75 
0°65 
0°45 
0°45 
0°40 
0°45 
0°45 ~0°104 ce. 
0°45 
0°65 
0°65 
a 
0°60 
0°85 
0°95 
1:80 
1-40 \ 
| 155 ~ 0'286 ce. 
| 1°30 j 
1°30 
1°45 
175 
1°65 \ 
1°65 ~ 0°327 ce. 
1°85 
1°55 
1°60 
‘ ae Fig. 62.—Secretion of bile before and after juglandin and sodium 
eee, salicylate. 5 grains of juglandin in 2 ce. of rectified spirit, 2 cc. 
1:95 of bile, and 5 ce. of water injected into the duodenum at 7 and 7’; 
3°40 20 grains of sodium salicylate in 1C cc. of water injected into the 
3°75 lower portion of the intestine at s. 
of secretion almost precisely the same as rhubarb (0°32 cc.) and leptandria 
(0°31 cc.). 
Necrorsy.—Slightly increased redness of the duodenum, and slight pur- 
gation. 
Result of Experiment with Juglandin.—lIt is a mild hepatic stimulant and a 
mild purgative, and seems eminently worthy of the attention of the physicians 
of this country. 
ACTION oF BENzoIC ACID AND ITS COMPOUNDS. 
Benzoic acid is said to act as a stimulant of the system generally, and 
particularly of the kidneys, mucous membrane of the bladder, and bronchial 
glands. It is nowhere stated to be a cholagogue. Yet it is sometimes used 
empirically in hepatic affections. TANNER, in his “Practice of Medicine,” recom- 
mends ammonium benzoate in hepatic congestion with deficient urine, and 
