PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 221 
Necropsy.—Very slight increase of redness of the duodenal mucous mem- 
brane. No purgation. 
Experiment 64. Dog that had fasted eighteen hours. Weight 27:1 kilo- 
grammes (fig. 64)—Twenty grains of ammonium benzoate, dissolved in 25 cc. 
of water, were injected into the duodenum at 46. Within half an hour a 
| 
Experiment 64. 
Secretion of bile 
Secretion of bile | per kilogramme 
per 15”. of dog: per 
hour. 
ia antic te 
AMKAHMwoeRS 
AAA MNS * 
1°70 boas ce. 
1°80 
3°63 
4:05 
4°00 0°544 cc. 
2°50 
2°50 f 
2°50 0°37 ce. 
2:25 Fig. 64.—Secretion of bile before and afterammonium benzoate and atropia. 
2°30 20 grains of ammonium benzoate in 25 cc. of water injec ted into the 
———_ : duodenum at >; one-fifth of a grain of atropia sulphate injected into 
2°40 the jugular vein at a, a’, and a’. 
powerful stimulation of the liver ensued that lasted five hours, and would pro- 
bably have continued still longer had the experiment been continued. One-fifth 
of a grain of atropia sulphate, injected into the jugular vein at a, a’, and a’”— 
three-fifths of a grain in all—did not antagonise the action of the benzoate. 
Necropsy.—There was no purgation, the intestine being perfectly dry ; but 
the mucous membrane of the small intestine was considerably reddened to the 
extent of three feet below the pylorus. 
A repetition of experiments so entirely satisfactory was unnecessary ; never- 
theless, in Experiment 70 there was a reason for giving sodium benzoate, and 
hepatic excitement again resulted from it. 
VOL. XXIX, PART I. Bio 
