PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 225 
grammes (fig. 65).—20 grains of ammonium phosphate dissolved in 22 cc. of 
water, were injected into the duodenum at a. The subsequent increased bile- 
secretion. was decided and prolonged. Since tannin is employed as an astringent 
in cases of diarrhoea, 20 grains, dissolved in 20 cc. of warm water, were injected 
into a fresh portion of the small intestine (¢) ; but, as it did not affect the bile- 
secretion, it was not thought worth while to repeat the dose. 20 grains of 
sodium salicylate, in 10 cc. of water, were then injected into a fresh portion of 
the small intestine (s), and, within half-an-hour, its never-failing effect was 
evident. Obviously it stimulated the liver much more powerfully than the 
ammonium phosphate. At the beginning of the experiment, the coefficient of 
Experiment 65. 
Secretion of 
Secretion of | bile per kilo- 
bile per 15”. | gramme of dog: 
per hour. 
0°50 
0°45 te 
150 
ae 0-634 cc, 
tannin, and sodium salicylate. 20 grains of ammonium phosphate 
in 22 cc. of water injected into the duodenum at a; 20 grains of ~ 
tannin in 20 ce. of water injected at¢; 20 grains of sodium sali- 
cylate in 10 cc. of water injected at s. 
0°85 Fig. 65.—Secretion of bile before and after ammonium phosphate, 
} 0°329 ce. 
1°25 
2°50 ; 
2°65 ho 89 ce. 
secretion was 0:19 cc. per kilogramme of body-weight per hour; a fair average 
for a fasting dog. After the ammonium phosphate, it rose to the unusually 
high figure of 0-634 cc.; but after the sodium salicylate, it rose still higher to 
0°39 cc. The result of this experiment being apparently so unequivocal, it was 
not thought necessary to repeat it. Nevertheless, considering the small size of 
the animal (9°7 kilos.), and that the dose was the maximum dose for a man, 
VOL. XXIX. PART I. 3M 
