PHYSIOLOGICAL ACTION OF DRUGS ON THE SECRETION OF BILE. 229 
Necrorsy.—Ninety-seven ce. of liquid in the small intestine (30 cc. had 
been injected), but whether most of it had been secreted by the pancreas or by 
Lieberkiihn’s follicles was undetermined. There was no unusual redness of the 
intestinal mucous membrane. 
Experiment 68. Experiment 684. | 
Secretion Secretion | 
of bile of bile 
Secretion | per kilo- | Secretion | per kilo- 
of bile per | gramme of| of bile per | gramme of | 
15”. dog: per 15”; dog: per | 
hour. hour. 
ce. ee. | 
1°40 1°80 
1°42 1°70 
1°40 1°67 
\— 1°70 
1:40 ) (== 
1°45 0'265 cc.) 1°70 u 2 3 + o 6 d 8 
F 1°40 if : 72 0°314¢c.| Fig. 68.—Secretion of bile before and after jaborandi. 2 ce. of bile 
Lae 165 and 8 cc. of water injected into the duodenum at 6; 8 cc. of 
: 1°40 1°70 infusion of jaborandi with 2 cc. of bile injected at 7 and 7’ ; sali- 
1-40 ae yation began at s. 
: s— 1°70 
1°40 : 
1°50 
1°50 
1°55 
: 1°50 
: 1°60 
1°45 
j— 
1°50 
| 1.50 
1°60 
| | 60 
| 1-72 0°310 ce. 
. 1°55 
| 1°80 
) 1°55 
| 1°65 
| 1°50 
1°40 
1°70 
1:50 6 
1°35 1°70 Fig. 684.--Secretion of bile before and after jaborandi. At b, 2 cc. 
175 | of bile and 10 cc. of water ; at j and 7’ the same fluid, with 10 cc. 
infusion of 75 grains of jaborandi leaves injected into the 
duodenum. Salivation began at s. 
Experiment 684. Dog that had fasted eighteen hours. Weight 21°5 kilo- 
grammes (fig. 684).—Ten cc. of water with 2 cc. of bile were injected into the 
duodenum at 6, and the same fluid, with 10 cc. of aqueous infusion of jaborandi, 
was injected at 7 and again at 7’. As each cubic centimetre of the infusion 
contained the active principle of 7} grains of the leaves, 150 grains had been 
given. Salivation began half-an-hour after the first dose, and soon thereafter 
the bile-secretion rose, but to no great extent. It was observed in this experi- 
VOL. XXIX. PART I. 3N 
