231) PROFESSOR RUTHERFORD ON THE 
ment that the bronchial glands were much stimulated by the jaborandi, the 
respiratory cannula being completely obstructed by a watery mucus, which 
must have been secreted in the bronchi and trachea. 
Necropsy.—The jaborandi had traversed the whole length of the small 
intestine, which contained 107 cc. of a clear greenish fluid without mucous 
flakes. Thirty-six cc. of fluid had been injected; but how much of the remainder 
had been secreted by the pancreas and how much by Lieberkiihn’s follicles 
could not be determined. 
Result of Experiments with Jaborandi.—In doses that were much more 
than sufficient to excite the salivary glands, jaborandi produced only a slight 
increase in the biliary secretion. It is therefore to be regarded as a very 
feeble hepatic stimulant. 
ACTION OF SULPHATE OF MANGANESE. 
It is stated by Parerra (Op. xix. I. p. 635) that “C. G. GMELIN tried the 
effect of the sulphate of the protoxide of manganese on animals, and found 
that it caused vomiting, paralysis with convulsions, and inflammation of the 
stomach, small intestines, liver, spleen, and heart. He notices as a remark- 
able fact, the extraordinary secretion of bile produced by it, and which was 
so considerable that nearly all the intestines were coloured by it, and the 
large intestines had a wax-yellow colour communicated to them.” At the 
suggestion of PARErRA (/oc. cit.), its effects on the human subject were tested by 
Mr Urez, who found that, in doses of from 60 to 120 grains, it acts as a 
purgative and cholagogue. In a recent communication to the Lancet (1878, 
i. 882), Dr R. H. Goo.pen states that he has been in 
the habit of using the substance as a cholagogue for 
more than thirty years. He finds that, in doses 
of from ten to twenty grains, it produces large 
bilious evacuations. Ten grains he regards as a 
sufficient dose for ordinary purposes. This he 
dissolves in a tumbler of water, and adds some 
citrate of potash or magnesia. These statements 
rendered it desirable for us to test the action of this 
Halen: substance by our method of experiment. 
Fig. 69.—Secretion of bile before and ‘ ‘ 
” after sulphate of manganese. 60 Experiment 69. Dog that had fasted eighteen 
in 30 do cf otel aeRohtae nee hours. Weight 15 kilogrammes (fig. 69).—Think- 
the duodenum at m. 3 ° 
ing, from Parerra’s statement of the amount given 
to the human subject by Urs, that 60 grains of manganese sulphate would not 
be too large a dose for a dog, we injected that amount in 30 cc. of water 
1 z 3 4 
