PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILF. 233 
Experiment 714. Dog that had fasted eighteen hours. Weight 19-9 kilo- 
grammes (fig. 714)——One grain of acetate of morphia in 5 cc, of water was 
injected into the duodenum at m, and 2 grains in 10 cc. of water were injected 
at m’. No diminution of secretion was the result ; in short, the morphia did 
not appear to affect the secretion. As it seemed desirable to know whether 
Experiment 71a. 
Secretion 
Secretion of bile per 3 
of bile per kilogramme 
15”. of dog: per 
hour. 
| pies See ee o5 
ce. | 
aKa 
0°85 
0°80 ) 2 
0°70 : , 
0-70 i 0°15 ce. 
0°80 
ees 5 is) 
0°95 
110 
0°95 
7 —_—— 
0°90 1 
0°85 
ae ae ce. 
0:90 
A 0-5 
1°05 
3°05 
3°35 7 ; 
2°45 ho 565 ce. q 
2°40 
2°15 
2°30 Fig. 71A.—Secretion of bile before and after morphia and sodium 
. salicylate. 1 grain of morphia acetate in 5 cc. of water 
i injected into the duodenum at m; 2 grains in 10 ce. of 
s water at m’; 20 grains of sodium salicylate in 10 cc. of water 
injected into the duodenum at s. 
or not the liver of an animal so narcotised could be excited by an appropriate 
stimulant, 20 grains of sodium salicylate in 10 cc. of water were injected 
into the duodenum at s. Powerful and prolonged excitement of the liver 
was the result. 
Necropsy.—Slightly increased redness of the duodenal mucous mem 
brane. Evidence of slight purgative action in the upper part of the small 
intestine. 
Result of Experiments with Morphia.—Three grains of morphia acetate did 
not affect the secretion of bile. 
VOL, XXIX. PART I. 3 0 
