934 PROFESSOR RUTHERFORD ON THE 
ACTION OF HyOSCYAMUS. 
As extract of hyoscyamus is often administered with cholagogue 
substances, it is import- 
ant to know whether or 
not it diminishes the 
secretion of bile. The 
dose of this substance 
for a man is from 5 to 
10 grains. 
Experiment 72. Dog 
that had fasted eighteen 
hours. Weight 21 kilo- 
grammes ° (fig. 72).—2 
Fig. 72.—Secretion of bile before and after hyoscyamus, 2 grains of TA] a 
~ extract of hyoscyamus with 8 ec. of water injected into the duodenum ee of aqueous eX 
ath, h’, h’, and hi”, tract of hyoscyamus in 3° 
cc. of water were inject- 
ance: ed into the duodenum at 
: = fee h, h’, h’, and h’”, 8 grains 
ee Secretion | , Secretion being given in all. It 
Secretion | of bileper || Secretion of bile per = i i 
of bile per kilogramme | of bile per kilogramme was impossible, from this 
15”. of dog: per | 15”. | of dog: per , . 
hour, | | hour, single experiment, to say 
as Se : —|————|—— _ whether. or not; them 
io | 145 in the secretion was 
ai 1°55 
ee i due to the hyoscyamus ; 
1°65 1°50 p 
ee | uae but the unusually high 
1°65 1°30 : ° 
ee fos Pigs | (58 coefficient of secretion 
1°60 1°35 1 1 
| au | ae in the earlier part of 
h re. | hi’ Reet. ° 7 
a a | oan the experiment (0°311 
1°65 1°10 1 
465 | 0-90 cc. per kilogramme per 
io | ae ) hour) favoured the con- 
es j | 0° 20, . 
Ee Al | p80 j kei clusion that the fall 
1°55 | was not due to the 
a) ae anal [a Re 
Necropsy.—Mucous membrane of small intestine pale and dry. 
Experiment 73. Dog that had fasted eighteen hours. Weight 16:8 kilo- 
grammes (fig. 73).—To decide the point left in doubt by the previous experi- 
ment, larger doses of the drug were administered. Eight grains of extract of 
