PHYSIOLOGICAL ACTION OF DRUGS ON THE SECRETION OF BILE. 239 
The post-mortem examination in this case was not made until fourteen hours 
after death. 
In Experiment 75 the administration of 20 grains of calomel in two doses of 
10 grains was followed by a powerful purgative effect and by a slight increase 
in the bile-secretion ; but considering that the coefficient of secretion never rose 
above 0'133 cc., it is evident that the increased activity of the liver was very 
trifling. Yet one would be apt to be 
misled by such an experiment as this, 
had we, after the manner of Rouric, 
failed to show the amount of bile secreted 
in relation to the weight of the animal. 
Judging from subsequent experiments, 
Fig, 75a.—Secretion of bile before and after calomel it can scarcely be doubted that the trifling 
given without bile. 10 grains calomel in 3cec. . - , : : 
water injected into duodenum at c, and the same INCYrease of secretion in this experiment 
cece ats. had nothing to do with the calomel. 
ae Experiment 75s. Dog that had 
xXperiment /OA, ¥ < : 
fasted eighteen hours. Weight 7 kilo- 
: 
Secretion Secretion | grammes (fig. 75 A).—10 grains of calo- 
Secretion | of bile per Secretion | of bile per 1s Yaa : 
of bile per |kilogramme|| of bile per |kilogramme| Mel in 3 cc. water were injected into the 
n, f dog: 15”. f dog : ; ‘ 
m Ser hou, per hour, | duodenum at ¢, and again at c’ (20 grains 
| given in all. 
ce. ce. | aes I 
Sea nie | NECROPSY. The upper third of the 
he | cee hoa cc. | Small intestine was semi-distended with 
0°85 aad) ORL. a brown, somewhat clear, viscous fluid 
0-75 | eee | . s ae. 
0°75 fey ote | with patches of green, thus affording 
a | ‘oa 5 é : c 
on7s ee O36 ce. evidence of purgative action. The gas- 
0°87 | 0°45 tric mucous membrane was pale, and 
0°62 | 0°50 ee : : 
0°67 | 0°55 ““ee. | contained some viscous fluid of a brown- 
0-60 0°45 ; 
ish colour, with a patch of green matter 
clinging to the mucous membrane near 
to the pylorus, which was evidently due to the entrance of calomel from the 
duodenum, for a little unchanged calomel was perceptible at the margin of 
the patch. The cause of the brown colour of the fluid was not apparent. The 
necropsy was in this case performed fifteen hours after death. 
The exceptionally high secretion in Experiment 754 was probably due to 
the circumstance that the animal was a young one. In proportion to the weight 
of the animal, more bile is secreted by a young than by a full-grown dog. The 
administration of calomel was followed by decided purgation and by diminished 
bile-secretion. 
Experiment 758. Dog that had fasted eighteen hours. Weight 12°9 kilo- 
erammes (fig. 758).—The secretion of bile was unfortunately very irregular in 
