PHYSIOLOGICAL ACTIONS*OF DRUGS ON THE SECRETION OF BILE. 245 
Necropsy.—The state of the duodenum and its contents was precisely 
similar to that described in the preceding experiment. 
Experiments 784 and 788 prove conclusively, and in a very striking manner, 
that mercuric chloride is a hepatic stimulant ; and that it is a powerful one is 
shown by the fact that in Experiment 784, 4 grain raised the bile-secretion per 
kilogramme of body-weight to 0°472 cc. per nites while in Experiment 788 it 
raised the secretion to 0°557 cc. per kiiogramme per hour. 
The contrast between the last two experiments with mercuric chloride and 
those with calomel is remarkable, both as regards the effect on the /iver, and 
on the intestine ; for while the mercuric chloride powerfully excited the liver, 
but scarcely affected the intestinal glands, notwithstanding its immediate con- 
tact with the latter, the calomel did not stimulate the liver, but did powerfully 
excite the intestinal glands. 
This startling result so clearly established by these experiments is a striking 
_ proof of the value of this method of investigation as an auxiliary to clinical 
observations on man. 
To render these experiments still more complete, we in the next two cases 
injected into the duodenum a minute dose of mercuric chloride along with 
calomel and bile. These experiments are valuable in showing the very remarkable 
stimulation of the liver that followed an unusually small dose of the mercurial. 
Experiment 78c. Dog that fasted seventeen hours. Weight 9:9 kilo- 
Experiment 78c. 
Secretion || Secretion 
Secretion of bile per Secretion of bile per | 
of bile per | kilogramme || of bile per | kilogramme | 
LD of dog: per | 15”. of dog: per 
hour. hour. 
AE rs | i 
ee. ce. | 
1°2 1°65 
se 1°80 
b— 0°48 ce. iy 4s) : 
11 1°85 I 72 ce. 
1:3 IEG 
™m —— 1°50 1 2 3 4 
| 1°4 1°35 
1°65 1°15 Fig. 78c.—Secretion of bile before and after 
1°50 | 115 mercuric chloride and calomel given 
\ with bile. 0°5 cc. bile and 2 ce. 
7 water injected into duodenum at 0.- 
gy grain mercuric chloride and 1 grain 
calomel in the same fluid injected into 
duodenum at m. 
|grammes (fig. 78c).—0°5 cc. bile and 2 cc. water were injected into the 
‘|duodenum at 6, and 5 grain of corrosive sublimate and 1 grain of calomel 
\in the same fluid were injected at m. 
VOL, XXIX. PART I. 3R 
