246 PROFESSOR RUTHERFORD ON THE 
Necropsy.—Slightly increased vascularity of mucous membrane of duo- 
denum. No purgation. : 
In the above experiment, the bile-secretion per hour rose to 0°72 cc. per 
kilogramme of body-weight, but the secretion was so high—0-48 cc.—before 
the drug was given, that it was difficult to know exactly how to regard the 
very high figure first mentioned. Another experiment was therefore desirable. 
Experiment 78D. Dog that had fasted seventeen hours. Weight 18:4 kilo- 
grammes (fig. 78D).—.45 grain of corrosive sublimate and 1 grain of calomel 
mixed with 2 cc. water and 0°5 cc. bile were injected into the duodenum at m, 
and the same dose was repeated at m’ and at m”. 
Experiment 78D. 
Secretion 
Secretion of bile per 
{ of bile per kilogramme 
15”. of dog: per 
hour. 
Se} 
0°228 ce. 
HHHOOG 
PDonwnvas 
7 
to 
bo oro eo NO HS 
SNSNWWSBO 
f F. 
Vit 
Heer Do 
“Tod ROO 
aad 
PSar ar 
or 
1 2 3 4 5 
Fig. 78p.—Secretion of bile before and after mercuric 
chloride and calomel given with bile. 5 grain 
mercuric chloride with 1 grain calomel in 0°5 cc. 
bile and 2 ec, water injected into duodenum at m, 
m', and m” respectively. 
Necropsy.—Considerable irritation of the mucous membrane of the upper 
