ew 
PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE, 247 
fourth of small intestine. The contents of this portion of the canal indicated 
considerable purgative action. 
The increase of bile-secretion in Experiment 78D is very remarkable, not 
only for its absolute extent, but also because of the smallness of the dose that 
occasioned it.. The amount of bile secreted per kilogramme of body-weight 
rose to the very high figure of 0°85 cc. per hour. The effect of so small a 
dose as 3}, grain of corrosive sublimate in this experiment is very remarkable, 
for the animal was rather larger than those employed in Experiments 78A 
and 7838, where ; and even ¢ grain had not so powerful an effect. Consider- 
ing the result of Experiment 764, it is not in the least likely that the addition 
of one grain of calomel to the dose of the mercuric chloride had anything to do 
with the difference in the result. We can only suggest, by way of explanation, 
that possibly in some cases the liver is more susceptible to a mercurial stimulus 
than it is in others. 
With the mercuric chloride we had given bile in every case save in Experi- 
ment 78, and that was the only instance where the result was negative ; we 
therefore thought it desirable to perform another experiment, with mercuric 
chloride given without bile. 
Experiment 78E. 
Seore- | Sfbile per | Sete. | of bile per 
tion of il re per || tion of tail oe ee 
bile per ogramme || +16 per | Kilogramme 
15” of dog: per | 15” of dog: per 
: hour. | fee hour: 
ce. i, ee, 
1°80 || 1°35 
1:70 || 1°50 
1°50 1°50 
1°85 1°55 
1°45 Neel so 
1°35 ‘ 1°30 
1°30 lo 388 ce. 1°65 
1:10 1°70 
c—— 1°50 
115 1°30 
0°80 ce’ —— 
1°45 | 1°90 
lost | 1:70 0°50 cc Fig. 78n.—Secretion of bile before and after mercuric chloride given without bile. 
1:25 1°65 : 2 orain mercuric chloride in 6 cc. water injected into duodenum at ¢, c’, and 
i 1°45 ce’. (2 grain given in all.) 
q 1°50 
1:10 |) 1°45 
¢ —— || 1°60 
Experiment 78r. Dog that had fasted seventeen hours. Weight 134 
kilogrammes (fig. 78E).—+4 grain corrosive sublimate in 6 cc. water was 
injected into the duodenum at c, and the same dose was repeated at c’ and 
¢. The liver was stimulated, the coefficient of bile-secretion rising as high 
as 05 cc. But the experiment is inconclusive, for a reason mentioned in the 
necropsy. 
