348 



DR THOMAS E. FRASER ON STROPHANTHUS HISPIDTJS. 



duced no movement ; but the muscles of the limbs and body still actively contracted 

 when galvanised. The pupils continued to be dilated. Forty-one min. after death, the 

 muscles of the body no longer contracted under galvanic stimulation, and they had 

 become somewhat hard. 



Alcoholic Extract free from Oil, &c. 



As the extract, containing oil and other substances soluble in ether, is not a suitable 

 preparation with which to define the lethal activity of Strophanthus, it was not used 

 for this purpose. On the other hand, either the alcohol extract after treatment with 

 ether (see p. 994), # or the alcohol extract obtained after the seeds had been thoroughly 

 extracted with ether (see p. 994),* provided, in each case, that only a moderate 

 quantity of strong alcohol had been used in the extraction, is entirely suitable for this 

 purpose, as both extracts are of fairly constant composition, and are entirely soluble 

 in water. 



The experiments made with extract free from oil have been so arranged in Tables XII. 

 and XIII. as to show the minimum quantity capable of producing death in frogs and 

 in rabbits, when the administration was by subcutaneous injection. 



Table XII. — Minimum-Lethal Dose of Extract for Frogs. 



No. of 

 Experiment. 



Weight of 

 Animal. 



Dose in 

 Grains. 



Dose per 100 



Grains 

 of Animal. 



Kesult. 



X. 



410 grs. 



0-0002 



0-00005 



Recovery. Very slight effects. 





XL 



440 „ 



0-00025 



0-000056 



Recovery. Slight effects. 





XII. 



505 „ 



0-000312 



0-00006 



Death in more than 4 hours. 





XIII. 



485 „ 



0-000375 



0-000077 



Death in more than 3 hours. 





XIV. 



450 „ 



0-000437 



0-000097 



Death in less than 3 hours. 





XV. 



430 „ 



0-0005 



0-00011 



Death in more than 2 hours. 





XVI. 



445 „ 



o-ooi 



0-00022 



Death in more than 1 hour and 50 



min. 



Table XIII. — Minimum-Lethal Dose of Extract for Rabbits. 



No. of 

 Experiment 



Weight of 

 Animal. 



Dose in 

 Grains. 



Dose per lb. 

 of Animal. 



Result. 



XVII. 



3 lbs. 12 oz. 



0-0175 



0-0046 



Recovery. Distinct effects. 



XVIII. 



3 lbs. 8 oz. 



0-02 



0-0057 



Death in 1 hour and 10 min. 



XIX. 



3 lbs. 6 oz. 



o-i 



0-029 



Death in 47 min. 



Trans. Roy. Soc. Edin., vol. xxxv. part iv., 1890. 



