3.">0 DR THOMAS R. FRASEE ON STROPHANTHUS HISPIDUS. 



Lying flaccid on the abdomen. No cardiac impact could be seen. A sciatic nerve 

 was exposed and galvanised, without any response. Galvanic stimulation was 

 also applied directly to the exposed thigh muscles, but weak currents failed to 

 produce contractions, and strong currents a mere depression or dimpling of the 

 surface of the muscle. The heart was exposed, and it was found to be motionless, 

 with the auricles large and distended, and the ventricle small and pale, while 

 mechanical and galvanic stimulation alike failed to excite anv movement. On the 

 third day, general rigor was present. 



Experiment XVI. — To a frog, weighing 445 grains, O'OOl grain of extract was 

 administered by subcutaneous injection. The frog soon became restless ; but for 24 

 mill, the posture was normal, and the respiratory movements were maintained at the 

 original rate of 16 per 10 sec. In 29 min., however, the fore-feet were often rubbed 

 over the muzzle, the throat was retracted, and the respirations were irregular. In 

 32 min., the respirations were frequently interrupted by long pauses, and the thoracic 

 extremities were extended. In 36 min., the respirations were 14 per 10 sec, and 

 very irregular, the thoracic extremities were still extended, and the fore-feet were 

 every now and then rubbed over the muzzle. In 39 min., the respirations were 7 per 

 10 sec, and still very irregular. In 1 hour 13 min., the thoracic extremities had 

 become weak, the thorax sometimes rested on the table, respiratory movements had 

 entirely ceased, and the skin was pale. The frog, however, could still jump actively. 

 In 1 hour 34 min., the frog could no longer jump normally, and, after an imperfect 

 jump, the pelvic extremities did not at once reassume the normal flexed position. 

 In 1 hour 54 min., the condition remained as last noted, and fairly active reflexes 

 could still be excited. The observations were now interrupted until the following day, 

 when, 26 hours after the administration, the frog was in general rigor. 



Three experiments were made with this extract on rabbits for the purpose of observing 

 the general action. 



Experiment XVII. — A rabbit, weighing 3 lbs. 12 oz., received by subcutaneous 

 injection 0"0175 grain of extract dissolved in 25 minims of distilled water. Before the 

 injection, the respirations were 27, and the cardiac impacts 40, per 10 sec. In 18 

 min., the respirations were 23, and the cardiac impacts 40, per 10 sec. In 20 min., 

 the respirations suddenly fell to 5 per 10 sec, and they became laboured. The 

 cardiac impacts also diminished in number, only 18 being felt in 10 sec, and they 

 were feeble and difficult to define. The rabbit was restless and the head unsteady. 

 In 22 min., the respirations became more frequent, their rate being 15 per 10 sec, 

 and inspiration was not so markedly laboured. In 24 min., fibrillary twitches were 

 seen at the flanks. In 32 min., the respirations were 14 per 10 sec, inspiration 

 being still prolonged, and the cardiac impacts appeared to be fairly frequent, but 

 it was impossible to define them accurately on account of incessant fibrillary twitches. 

 In 46 min., the respirations again became infrequent, only 8 occurring in 10 sec, 

 and they were again very laboured. In 50 min., the respirations improved in character 



