DR THOMAS R. FRASER ON STROPHANTI! US HISPIDUS. 351 



and rate, the latter being 17 per 10 sec. In 59 min., another disorder of inspiration 

 again suddenly occurred, the rate becoming 6 per 10 sec, and the character laboured, 

 with prolonged inspiration and abrupt expiration. In 1 hour, tremors of the head 

 occurred for a few seconds, after which the rabbit again became quiet, and assumed 

 a normal posture. The respirations, however, continued infrequent, and retained the 

 abnormal characters above described. In 1 hour 20 min., an improvement was 

 noted, the respirations were 10, and the cardiac impacts 39, per 10 sec. ; the posture 

 was normal, and there w r ere no tremors of the head. In 2 hours, the respirations 

 were 23 per 10 sec, and almost normal in character and rhythm, and the cardiac 

 impacts were strong, and 41 per 10 sec. The rabbit sat normally, and moved spon- 

 taneously from place to place without difficulty. No urine nor faeces had been passed 

 during the experiment. On the following day, the rabbit appeared to be perfectly 

 well. 



Experiment XVIII. — The rabbit used in this experiment weighed 3 lbs. 8 oz. ; 

 and, before the administration, the respirations were 12 per 10 sec, but the cardiac 

 impacts were too indistinct to allow of accurate counting with the hand. The dose of 

 extract was 0'02 grain, which was given also by subcutaneous injection of a solution in 

 distilled water. In 12 min., the rabbit was restless, and the respirations were 13 per 



10 sec In 19 min., the respirations were 11, and in 25 min., they were 9 per 10 sec 

 In 34 min., expiration became abrupt, and now the cardiac impacts were more distinct, 

 36 being counted in 10 sec. In 46 min., the head was shaking; the respirations were 



11 per 10 sec, with abruptness of inspiration; and the rabbit was lying extended on 

 the abdomen. In 56 min., the respirations were 10 per 10 sec, inspiration continuing 

 abrupt ; the thoracic extremities had yielded, so that the chest was no longer supported 

 properly ; and tremors occurred incessantly in the head and thorax, and prevented the 

 counting of the cardiac impacts. In 59 min., the mouth was resting on the table, 

 fibrillary twitches occurred over the body and neck, the respirations were 6 per 

 10 sec, and the pupils were dilated. In 1 hour 3 min., the side of the head was 

 resting on the table, the respirations were 5 per 10 sec, and the cardiac impacts, 

 which now could again be counted as the tremors had ceased, were 19 per 10 sec, 

 and irregular. In 1 hour 5 min., and also in 1 hour 6 min., the rabbit made 

 unsuccessful efforts to raise the head, and some struggles, apparently for breath, 

 occurred. The respirations were very shallow, and at the rate of about 4 per 10 

 sec. In 1 hour 12 min., respiration had almost ceased, the cardiac impacts were 13 

 per 10 sec, and the conjunctiva was sensitive. In 1 hour 13 min., a few feeble 

 convulsive movements of the limbs occurred, the pupils further dilated, and then all 

 movement ceased. At various times during the experiment urine and faeces had 

 been passed. 



One min. after death, the heart was exposed; it was twitching feebly at the 

 rate of 5 per 10 sec, but all spontaneous movements ceased in five minutes. The 

 pupils had now become smaller. Five min. after death, the strongest galvanic 



VOL. XXXVI. PART II. (NO. 16). 3 I 



