:;;>•_> 



DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



stimulation from a Daniell's cell and Du Bois Reymond's induction apparatus failed 

 to excite any movement when applied to the sciatic nerves, and it excited only 

 feeble twitches of the thigh muscles when directly applied to them. Eight min. 

 after death, the thigh muscles no longer contracted, even when stimulated with 

 the strongest interrupted currents, and the muscles were now found to be acid in 

 reaction. Ten min. after death, galvanic stimulation of the heart produced a single 

 contraction restricted to the chamber stimulated ; but 39 min. after death, it no 

 longer did so, and the muscle of the left ventricle was then found to be acid 

 in reaction. 



Strophanthin. 



In order to determine the general effects of strophantin, as well as to define its mini- 

 mum-lethal dose, experiments were made with a specimen obtained by the process 

 described at pages 1009 and 1010. * 



In Tables XIV. and XV. these experiments are so recorded as to exhibit the mini- 

 mum-lethal dose by subcutaneous injection for frogs and for rabbits. 



Table XIV. — Minimum- Lethal Dose of Strophanthin for Frogs. 



No. of 



Experiment. 



Weight of 

 Animal. 



Dose in 

 Grains. 



Dose per 100 

 grains of 

 Animal. 



Result. 



XX. 



450 grs. 



0-000125 



0-000027 



Recovery. Very slight effects. 



XXI. 



485 „ 



0-0001875 



0-000038 



Recovery. Very slight effects. 



XXII. 



475 „ 



0000195 



0-000041 



Recovery. Slight effects. 



XXIII. 



483 „ 



0-00025 



0-000051 



Death in less than 3 hours and 40 minutes. 



XXIV. 



460 „ 



0-00025 



0-000054 



Death in more than 2 hours and 50 minutes. 



XXV. 



450 „ 



0-0005 



0-00011 



Death in less than 2 hours and 50 minutes. 



XXVI. 



412 „ 



o-ooi 



0-00024 



Death in more than 2 hours and 28 minutes. 



XXVII. 



480 „ 



0-002 



0-00041 



Death in less than 1 hour 49 minutes. 



XXVIII. 



375 „ 



0005 



0-0013 



Death in less than 2 hours 15 minutes. 



XXIX. 



477 „ 



001 



0-002 



Death in less than 1 hour 43 minutes. 



* Trans. Roy. Soc. Edin., vol. xxxv. part iv., 1890. 



